PURPOSE: Preoperative radiotherapy and chemotherapy are important in treating advanced oral cancer. We attempted to elucidate predictive factors for the histologic response to preoperative radiotherapy or chemoradiotherapy. PATIENTS AND METHODS: Forty-three patients with locally advanced cancer of the oral cavity and oropharynx were treated preoperatively with radiotherapy (50 Gy); surgery included modification of the resected area to preserve organ function. RESULTS: Hemoglobin level and histologic differentiation were independent factors significantly associated with the histologic response by multivariate analysis. Locoregional failure occurred only in patients with poor histologic response, and there was a significant difference in the 5-year survival rate between patients with good and poor responses (84% vs 32%). Multivariate analysis indicated that the histologic response at the primary site and the number of metastatic lymph nodes were prognostic factors. CONCLUSION: We identified predictive factors for a good response to preoperative therapy and found a high survival rate in patients with a good response.
PURPOSE: Preoperative radiotherapy and chemotherapy are important in treating advanced oral cancer. We attempted to elucidate predictive factors for the histologic response to preoperative radiotherapy or chemoradiotherapy. PATIENTS AND METHODS: Forty-three patients with locally advanced cancer of the oral cavity and oropharynx were treated preoperatively with radiotherapy (50 Gy); surgery included modification of the resected area to preserve organ function. RESULTS: Hemoglobin level and histologic differentiation were independent factors significantly associated with the histologic response by multivariate analysis. Locoregional failure occurred only in patients with poor histologic response, and there was a significant difference in the 5-year survival rate between patients with good and poor responses (84% vs 32%). Multivariate analysis indicated that the histologic response at the primary site and the number of metastatic lymph nodes were prognostic factors. CONCLUSION: We identified predictive factors for a good response to preoperative therapy and found a high survival rate in patients with a good response.
Authors: Oliver Driemel; Tobias Ettl; Oliver Kölbl; Torsten E Reichert; Bernd V Dresp; Jürgen Reuther; Hans Pistner Journal: Strahlenther Onkol Date: 2009-05-15 Impact factor: 3.621
Authors: D Wangsa; M Ryott; E Avall-Lundqvist; F Petersson; G Elmberger; J Luo; T Ried; G Auer; E Munck-Wikland Journal: Br J Cancer Date: 2008-09-02 Impact factor: 7.640