PURPOSE: To evaluate the efficacy of external beam radiation therapy (EBRT) for differentiated thyroid carcinomas. METHODS: Forty-two patients with a locally advanced or recurrent differentiated thyroid carcinoma received high-dose EBRT. Thirty-three patients had local-regional disease and 9 patients also had asymptomatic disease metastases. Twenty patients (48%) had macroscopic local-regional disease before EBRT. RESULTS: The 5-year outcomes for the overall population and for the subset of those without distant metastases before EBRT were local-regional control (88% and 89%, respectively), cause-specific survival (80% and 86%, respectively), and overall survival (54% and 60%, respectively). Local-regional control was improved for patients with microscopic residual disease compared with macroscopic disease, those with previously untreated tumors, and for those who received more than 64 Gy. CONCLUSION: EBRT increases the likelihood of local-regional control for patients with locally advanced differentiated thyroid carcinoma.
PURPOSE: To evaluate the efficacy of external beam radiation therapy (EBRT) for differentiated thyroid carcinomas. METHODS: Forty-two patients with a locally advanced or recurrent differentiated thyroid carcinoma received high-dose EBRT. Thirty-three patients had local-regional disease and 9 patients also had asymptomatic disease metastases. Twenty patients (48%) had macroscopic local-regional disease before EBRT. RESULTS: The 5-year outcomes for the overall population and for the subset of those without distant metastases before EBRT were local-regional control (88% and 89%, respectively), cause-specific survival (80% and 86%, respectively), and overall survival (54% and 60%, respectively). Local-regional control was improved for patients with microscopic residual disease compared with macroscopic disease, those with previously untreated tumors, and for those who received more than 64 Gy. CONCLUSION:EBRT increases the likelihood of local-regional control for patients with locally advanced differentiated thyroid carcinoma.
Authors: M Luster; S E Clarke; M Dietlein; M Lassmann; P Lind; W J G Oyen; J Tennvall; E Bombardieri Journal: Eur J Nucl Med Mol Imaging Date: 2008-10 Impact factor: 9.236
Authors: David L Schwartz; Mark J Lobo; K Kian Ang; William H Morrison; David I Rosenthal; Anesa Ahamad; Douglas B Evans; Gary Clayman; Steven I Sherman; Adam S Garden Journal: Int J Radiat Oncol Biol Phys Date: 2008-12-25 Impact factor: 7.038
Authors: Marshall Tulloch-Reid; Monica C Skarulis; Steven I Sherman; Nicholas J Sarlis; Libero Santarpia Journal: Anticancer Res Date: 2009-11 Impact factor: 2.480
Authors: Joan Manel Gasent Blesa; Enrique Grande Pulido; Mariano Provencio Pulla; Vicente Alberola Candel; Juan Bautista Laforga Canales; Miguel Grimalt Arrom; Patricia Martin Rico Journal: J Thyroid Res Date: 2010-04-13