| Literature DB >> 16360590 |
Abstract
Data from intravenous tissue plasminogen activator studies have shown rapidly diminishing clinical benefit beyond 3 hours when noncontrast CT is used for treatment triage. Newer trials, such as the Desmoteplase in Acute Ischemic Stroke trial, have now successfully pushed the time window out to 9 hours using the concept of penumbral imaging and treatment of the perfusion-diffusion mismatch. Advanced imaging with CT or MR imaging protocols is providing a means for rational physiologic selection and outcomes assessment in stroke treatment.Entities:
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Year: 2005 PMID： 16360590 DOI： 10.1016/j.nic.2005.08.002
Source DB: PubMed Journal: Neuroimaging Clin N Am ISSN： 1052-5149 Impact factor: 2.264