BACKGROUND AND OBJECTIVE: To evaluate the ability of optical coherence tomography (OCT) (a noncontact, high-resolution imaging technique that generates detailed cross-sectional images of tissue structure) to image and document acute response to trauma in the larynx. MATERIALS AND METHODS: Porcine larynges were dissected to expose the vocal cords. Vocal cords were imaged with 1310 nanometer (nm) light source with a bandwidth of 75 nm at 1 frame/second (s). Vocal cord injuries were simulated by applying topical phenolic acid, injecting titanium dioxide into the submucosa, and carbon dioxide laser irradiation. RESULTS: The epithelium, basement membrane, and lamina propria were clearly delineated, and the effect of each intervention could be monitored as lesions progressed. The OCT image corresponded closely with histology. CONCLUSION: OCT is a powerful imaging tool with the potential for use in real time and has potential for multiple clinical applications in the larynx.
BACKGROUND AND OBJECTIVE: To evaluate the ability of optical coherence tomography (OCT) (a noncontact, high-resolution imaging technique that generates detailed cross-sectional images of tissue structure) to image and document acute response to trauma in the larynx. MATERIALS AND METHODS: Porcine larynges were dissected to expose the vocal cords. Vocal cords were imaged with 1310 nanometer (nm) light source with a bandwidth of 75 nm at 1 frame/second (s). Vocal cord injuries were simulated by applying topical phenolic acid, injecting titanium dioxide into the submucosa, and carbon dioxide laser irradiation. RESULTS: The epithelium, basement membrane, and lamina propria were clearly delineated, and the effect of each intervention could be monitored as lesions progressed. The OCT image corresponded closely with histology. CONCLUSION: OCT is a powerful imaging tool with the potential for use in real time and has potential for multiple clinical applications in the larynx.
Authors: Giriraj K Sharma; Lily Y Chen; Lidek Chou; Christopher Badger; Ellen Hong; Swathi Rangarajan; Theodore H Chang; William B Armstrong; Sunil P Verma; Zhongping Chen; Ram Ramalingam; Brian J-F Wong Journal: J Biomed Opt Date: 2021-08 Impact factor: 3.170
Authors: Tiffany T Pham; Lily Chen; Andrew E Heidari; Jason J Chen; Alisa Zhukhovitskaya; Yan Li; Urja Patel; Zhongping Chen; Brian J F Wong Journal: Lasers Surg Med Date: 2019-01-25 Impact factor: 4.025
Authors: M L Kaiser; M Rubinstein; D E Vokes; J M Ridgway; S Guo; M Gu; R L Crumley; W B Armstrong; Z Chen; B J F Wong Journal: Clin Otolaryngol Date: 2009-10 Impact factor: 2.597
Authors: Carolyn A Coughlan; Li-Dek Chou; Joseph C Jing; Jason J Chen; Swathi Rangarajan; Theodore H Chang; Giriraj K Sharma; Kyoungrai Cho; Donghoon Lee; Julie A Goddard; Zhongping Chen; Brian J F Wong Journal: Sci Rep Date: 2016-03-10 Impact factor: 4.379