UNLABELLED: This study compared production of IL-2, IFN-gamma, IL-4, IL-13, IL-5 and IL-10 in peripheral blood mononuclear cells from 20 children with autism spectrum disorder to those from matched controls. Levels of all Th2 cytokines were significantly higher in cases after incubation in media alone, but the IFN-gamma/IL-13 ratio was not significantly different between cases and controls. Cases had significantly higher IL-13/IL-10 and IFN-gamma/IL-10 than controls. CONCLUSION: Children with ASD had increased activation of both Th2 and Th1 arms of the adaptive immune response, with a Th2 predominance, and without the compensatory increase in the regulatory cytokine IL-10.
UNLABELLED: This study compared production of IL-2, IFN-gamma, IL-4, IL-13, IL-5 and IL-10 in peripheral blood mononuclear cells from 20 children with autism spectrum disorder to those from matched controls. Levels of all Th2 cytokines were significantly higher in cases after incubation in media alone, but the IFN-gamma/IL-13 ratio was not significantly different between cases and controls. Cases had significantly higher IL-13/IL-10 and IFN-gamma/IL-10 than controls. CONCLUSION:Children with ASD had increased activation of both Th2 and Th1 arms of the adaptive immune response, with a Th2 predominance, and without the compensatory increase in the regulatory cytokine IL-10.
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Authors: Dario Siniscalco; Anna Sapone; Catia Giordano; Alessandra Cirillo; Laura de Magistris; Francesco Rossi; Alessio Fasano; James Jeffrey Bradstreet; Sabatino Maione; Nicola Antonucci Journal: J Autism Dev Disord Date: 2013-11
Authors: Sheikh Fayaz Ahmad; Khairy M A Zoheir; Mushtaq Ahmad Ansari; Ahmed Nadeem; Saleh A Bakheet; Laila Yousef Al-Ayadhi; Mohammad Zeed Alzahrani; Othman A Al-Shabanah; Mohammed M Al-Harbi; Sabry M Attia Journal: Mol Neurobiol Date: 2016-06-25 Impact factor: 5.590