| Literature DB >> 16360153 |
W M W Cheung1, W W Ng, A W C Kung.
Abstract
Osteoblastic differentiation is an essential part of bone formation. Dimethyl sulfoxide (DMSO) is a water miscible solvent that is used extensively for receptor ligands in osteoblast studies. However, little is known about its effects on osteoblastogenic precursor cells. In this study, we have used a murine preosteoblast cell line MC3T3-E1 cells to demonstrate that DMSO effectively induces osteoblastic differentiation of MC3T3-E1 cells via the activation of Runx2 and osterix and is dependent upon the protein kinase C (PKC) pathways. We further demonstrated that prolonged activation of PKC pathways is sufficient to induce osteoblastic differentiation, possibly via the activation of PKD/PKCmu.Entities:
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Year: 2005 PMID： 16360153 DOI： 10.1016/j.febslet.2005.11.062
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124