| Literature DB >> 16360026 |
Zhao-Hui Wu1, Angela Mabb, Shigeki Miyamoto.
Abstract
In response to genotoxic stress, the PIDD protein promotes apoptosis downstream of the tumor-suppressor protein p53. In this issue of Cell, Janssens et al. (2005) demonstrate that, in response to such stress, PIDD forms a nuclear complex that enhances sumoylation of NEMO. This modification is important for the activation of the antiapoptotic transcription factor NF-kappaB.Entities:
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Year: 2005 PMID： 16360026 DOI： 10.1016/j.cell.2005.11.025
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582