| Literature DB >> 16359866 |
Eoin C Power1, C Robin Ganellin, David C H Benton.
Abstract
A series of partial structures of ketoconazole has been synthesized and tested for activity on the large conductance calcium-activated potassium channel (BK) in bovine smooth muscle cells. This has provided openers and blockers of the channel. The results suggest that the phenyl and phenoxy moieties are important for interaction with BK, whereas the imidazole group is unimportant. The properties of the phenoxy moiety seem to determine whether the compounds act to open or block the channel.Entities:
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Year: 2005 PMID： 16359866 DOI： 10.1016/j.bmcl.2005.11.001
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823