Literature DB >> 16359864

Synthesis and antihyperglycemic evaluation of various protoberberine derivatives.

Xiaoli Bian1, Langchong He, Guangde Yang.   

Abstract

Various berberine derivatives (2-17) were synthesized and their antihyperglycemic activities were evaluated in a model of beta-cell-membrane chromatography and a model of alloxan-induced diabetes mice. The results indicated that compounds 5 and 14 exhibited antihyperglycemic activity. Their structure-activity relationships were discussed.

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Year:  2005        PMID： 16359864     DOI： 10.1016/j.bmcl.2005.11.045

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Design, synthesis and mechanism study of novel natural-derived isoquinoline derivatives as antifungal agents.

Authors:  Wei Chen; Rui Zhang; Yang Chen; Pingbing Yu; Yuxin Lan; Haojian Xu; Simin Lei
Journal:  Mol Divers       Date:  2022-06-06       Impact factor: 2.943

Review 2.  Application of berberine on treating type 2 diabetes mellitus.

Authors:  Bing Pang; Lin-Hua Zhao; Qiang Zhou; Tian-Yu Zhao; Han Wang; Cheng-Juan Gu; Xiao-Lin Tong
Journal:  Int J Endocrinol       Date:  2015-03-11       Impact factor: 3.257

3.  Syntheses and Structure-Activity Relationships in Growth Inhibition Activity against Human Cancer Cell Lines of 12 Substituted Berberine Derivatives.

Authors:  Bo Wang; An-Jun Deng; Zhi-Hong Li; Nan Wang; Hai-Lin Qin
Journal:  Molecules       Date:  2020-04-18       Impact factor: 4.411

4.  Berberine and itraconazole are not synergistic in vitro against Aspergillus fumigatus isolated from clinical patients.

Authors:  Gao Lei; He Dan; Liu Jinhua; Yan Wei; Gao Song; Wang Li
Journal:  Molecules       Date:  2011-11-03       Impact factor: 4.411

Review 5.  Rhizoma coptidis as a Potential Treatment Agent for Type 2 Diabetes Mellitus and the Underlying Mechanisms: A Review.

Authors:  Qian Ran; Jin Wang; Lin Wang; Hai-Rong Zeng; Xiang-Bo Yang; Qin-Wan Huang
Journal:  Front Pharmacol       Date:  2019-07-22       Impact factor: 5.810

6.  Novel carbohydrate modified berberine derivatives: synthesis and in vitro anti-diabetic investigation.

Authors:  Liwen Han; Wenlong Sheng; Xiaobin Li; Attila Sik; Houwen Lin; Kechun Liu; Lizhen Wang
Journal:  Medchemcomm       Date:  2019-02-08       Impact factor: 3.597

7.  Screening active components from Rubus amabilis for pancreatic β-cells protection.

Authors:  Min Sun; Tiantian Zhu; Jinzhi Tong; Rezeng Caidan; Kaijin Wang; Guiqing Kai; Wenna Zhang; Lei Ru; Jiumei Pengcuo; Li Tong
Journal:  Pharm Biol       Date:  2020-12       Impact factor: 3.503

8.  Discovery of the First in Class 9-N-Berberine Derivative as Hypoglycemic Agent with Extra-Strong Action.

Authors:  Mikhail V Khvostov; Elizaveta D Gladkova; Sergey A Borisov; Nataliya A Zhukova; Mariya K Marenina; Yuliya V Meshkova; Olga A Luzina; Tatijana G Tolstikova; Nariman F Salakhutdinov
Journal:  Pharmaceutics       Date:  2021-12-12       Impact factor: 6.321
  8 in total

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