OBJECTIVE: To test a possible strategy to alleviate somatosensory deficits after stroke. METHODS: Here, we applied ischemic nerve block to the intact hand of patients with chronic stroke, which in healthy subjects elicits improvements in sensibility of the other hand. RESULTS: We found that sensibility in the affected hand improved with intact hand anesthesia, but not with intact foot anesthesia or no anesthesia. INTERPRETATION: We conclude that reduction of sensory input from the intact hand leads to site-specific improvements in tactile discriminative skills in the affected hand after the period of anesthesia, a potentially relevant finding in designing neurorehabilitative interventions.
RCT Entities:
OBJECTIVE: To test a possible strategy to alleviate somatosensory deficits after stroke. METHODS: Here, we applied ischemic nerve block to the intact hand of patients with chronic stroke, which in healthy subjects elicits improvements in sensibility of the other hand. RESULTS: We found that sensibility in the affected hand improved with intact hand anesthesia, but not with intact foot anesthesia or no anesthesia. INTERPRETATION: We conclude that reduction of sensory input from the intact hand leads to site-specific improvements in tactile discriminative skills in the affected hand after the period of anesthesia, a potentially relevant finding in designing neurorehabilitative interventions.
Authors: M Stephen Melton; Jeffrey N Browndyke; Todd B Harshbarger; David J Madden; Karen C Nielsen; Stephen M Klein Journal: Anesthesiology Date: 2016-08 Impact factor: 7.892
Authors: Nan Li; Ya Yang; David P Glover; Jiangyang Zhang; Manda Saraswati; Courtney Robertson; Galit Pelled Journal: J Neurotrauma Date: 2013-12-10 Impact factor: 5.269
Authors: Elisabeth Sens; Ulrike Teschner; Winfried Meissner; Christoph Preul; Ralph Huonker; Otto W Witte; Wolfgang H R Miltner; Thomas Weiss Journal: J Neurosci Date: 2012-08-22 Impact factor: 6.167