Literature DB >> 16358064

Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates.

Patrick Vallance1, Hannah D Bush, B James Mok, Ramon Hurtado-Guerrero, Herpreet Gill, Sharon Rossiter, Jonathan D Wilden, Stephen Caddick.   

Abstract

A range of pentafluorophenyl (PFP) sulfonate esters derived from the reaction of PFP vinyl sulfonate and various nitrones are shown to have significant inhibitory activity against the bacterial enzymes DDAH and ADI.

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Year:  2005        PMID： 16358064     DOI： 10.1039/b510709a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  Screening for dimethylarginine dimethylaminohydrolase inhibitors reveals ebselen as a bioavailable inactivator.

Authors:  Thomas Linsky; Yun Wang; Walter Fast
Journal:  ACS Med Chem Lett       Date:  2011       Impact factor: 4.345

2.  A continuous, fluorescent, high-throughput assay for human dimethylarginine dimethylaminohydrolase-1.

Authors:  Thomas Linsky; Walter Fast
Journal:  J Biomol Screen       Date:  2011-09-15

Review 3.  The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis.

Authors:  James Leiper; Manasi Nandi
Journal:  Nat Rev Drug Discov       Date:  2011-04       Impact factor: 84.694

4.  Ab initio QM/MM free-energy studies of arginine deiminase catalysis: the protonation state of the Cys nucleophile.

Authors:  Zhihong Ke; Hua Guo; Daiqian Xie; Shenglong Wang; Yingkai Zhang
Journal:  J Phys Chem B       Date:  2011-03-11       Impact factor: 2.991

5.  Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.

Authors:  Thomas W Linsky; Walter Fast
Journal:  Bioorg Med Chem       Date:  2012-08-03       Impact factor: 3.641

6.  Specific reactions of S-nitrosothiols with cysteine hydrolases: A comparative study between dimethylargininase-1 and CTP synthetase.

Authors:  Oliver Braun; Markus Knipp; Serge Chesnov; Milan Vasák
Journal:  Protein Sci       Date:  2007-06-28       Impact factor: 6.725
  6 in total

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