Literature DB >> 16357533

Brain tumors provide new clues to the source of cancer stem cells: does oncology recapitulate ontogeny?

Richard J Gilbertson1.   

Abstract

Recent studies of leukemia and solid tumors have provided compelling evidence for the existence of cancer stem cells, but the origin of these cells remains a matter of considerable debate. By comparing the gene expression profiles of ependymomas with those of cells in the normal developing nervous system, we were able to pinpoint radial glia as candidate stem cells of this brain tumor. These data suggest strongly that ependymomas arise directly from transformed radial glia and they provide a novel method that could be used to map the cell of origin of other types of cancer.

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Year:  2006        PMID： 16357533     DOI： 10.4161/cc.5.2.2319

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  6 in total

Review 1.  Tumor profiling: development of prognostic and predictive factors to guide brain tumor treatment.

Authors:  Stephen H Settle; Erik P Sulman
Journal:  Curr Oncol Rep       Date:  2011-02       Impact factor: 5.075

Review 2.  Molecular genetics of ependymoma.

Authors:  Yuan Yao; Stephen C Mack; Michael D Taylor
Journal:  Chin J Cancer       Date:  2011-10

3.  A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells.

Authors:  Sergey Malchenko; Simone Treiger Sredni; Hitoshi Hashimoto; Atsushi Kasai; Kazuki Nagayasu; Jianping Xie; Naira V Margaryan; Kaoru Seiriki; Rishi R Lulla; Richard E B Seftor; Lauren M Pachman; Herbert Y Meltzer; Mary J C Hendrix; Marcelo B Soares
Journal:  PLoS One       Date:  2015-03-31       Impact factor: 3.240

4.  Characterization of brain tumor initiating cells isolated from an animal model of CNS primitive neuroectodermal tumors.

Authors:  Sergey Malchenko; Simone T Sredni; Jerusha Boyineni; Yingtao Bi; Naira V Margaryan; Maheedhara R Guda; Yulia Kostenko; Tadanori Tomita; Ramana V Davuluri; Kiran Velpula; Mary J C Hendrix; Marcelo B Soares
Journal:  Oncotarget       Date:  2018-02-09

5.  Glioma stem cells are more aggressive in recurrent tumors with malignant progression than in the primary tumor, and both can be maintained long-term in vitro.

Authors:  Qiang Huang; Quan-Bin Zhang; Jun Dong; Yin-Yan Wu; Yun-Tian Shen; Yao-Dong Zhao; Yu-De Zhu; Yi Diao; Ai-Dong Wang; Qing Lan
Journal:  BMC Cancer       Date:  2008-10-22       Impact factor: 4.430

6.  Targeting fibroblast growth factor receptors to combat aggressive ependymoma.

Authors:  Walter Berger; Johannes Gojo; Daniela Lötsch; Dominik Kirchhofer; Bernhard Englinger; Li Jiang; Konstantin Okonechnikov; Daniel Senfter; Anna Laemmerer; Lisa Gabler; Christine Pirker; Andrew M Donson; Peter Bannauer; Pia Korbel; Carola N Jaunecker; Jens-Martin Hübner; Lisa Mayr; Sibylle Madlener; Maria T Schmook; Gerda Ricken; Kendra Maaß; Michael Grusch; Klaus Holzmann; Bettina Grasl-Kraupp; Sabine Spiegl-Kreinecker; Jennifer Hsu; Christian Dorfer; Karl Rössler; Amedeo A Azizi; Nicholas K Foreman; Andreas Peyrl; Christine Haberler; Thomas Czech; Irene Slavc; Mariella G Filbin; Kristian W Pajtler; Marcel Kool
Journal:  Acta Neuropathol       Date:  2021-05-27       Impact factor: 17.088
  6 in total

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