| Literature DB >> 16356833 |
Elena Morandi1, Chiara Zingaretti, Daniela Chiozzotto, Cinzia Severini, Alessandro Semeria, Wolfango Horn, Monica Vaccari, Roberto Serra, Paola Silingardi, Annamaria Colacci.
Abstract
Chemotherapy, as generally available, is of a limited value in curing malignant brain tumors (gliomas), which often develop resistance to drugs, becoming completely unresponsive to any standard therapeutic approach. Camptothecins, a family of topoisomerase I inhibitor drugs, represent a new promising treatment strategy and are currently under evaluation for testing the clinical efficacy. We selected a CPT-resistant sub-line (U87CPT-R) from U87-MG grade III-IV astrocytoma cells, and compared the expression profile of the two cell lines by cDNA-microarray, as a preliminary screening of the molecular mechanisms involved in the acquisition of CPT resistance in glioma cells. The relevant role of IL-1 beta overproduction as well as a generalised up-regulation of genes implicated in angiogenesis and inflammatory response are discussed in details.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16356833 DOI： 10.1016/j.canlet.2005.01.017
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679