NO-cGMP signaling in development and stem cells.

Despite the recognition that the NO-cGMP signaling pathway is involved in so many physiological and pathological events, a clear understanding of many of the functions of this signaling pathway remains elusive. Because of its pleiotropic and often transient actions, its modulation for therapeutic purposes in multiple pathological states is a complex issue. Recent work that combines the areas of developmental and stem cell biology and NO-cGMP signaling in various models may help us elucidate some of these functions and even discover novel actions for this signaling paradigm. This review will discuss some of the recent work in these areas, with additional focus on the nitric oxide receptor, soluble guanylyl cyclase.