Literature DB >> 1635670

Alzheimer's amyloid precursor protein accumulates within axonal swellings in human brain lesions.

T Ohgami1, T Kitamoto, J Tateishi.   

Abstract

By using a monoclonal antibody and polyclonal antibodies to human beta amyloid precursor protein (APP), we immunohistochemically examined axonal swellings (spheroids). The immunoreactivity of APP was observed in numerous spheroids, which were found around the areas of old cerebral infarctions, in the globus pallidus with Hallervorden-Spatz disease as well as in or around brain abscesses. The axonal swellings were not immunolabeled with beta protein. These results implied that APP accumulated in spheroids regardless of beta protein depositions.

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Year:  1992        PMID： 1635670     DOI： 10.1016/0304-3940(92)90651-m

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  20 in total

1.  Real-time PCR quantitation of FE65 a beta-amyloid precursor protein-binding protein after traumatic brain injury in rats.

Authors:  Morio Iino; Masato Nakatome; Yoshiaki Ogura; Harutoshi Fujimura; Hisanaga Kuroki; Hiromasa Inoue; Yukiko Ino; Tasuku Fujii; Toshiyuki Terao; Ryoji Matoba
Journal:  Int J Legal Med       Date:  2003-04-18       Impact factor: 2.686

2.  Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology.

Authors:  J E Galvin; B Giasson; H I Hurtig; V M Lee; J Q Trojanowski
Journal:  Am J Pathol       Date:  2000-08       Impact factor: 4.307

Review 3.  The back and forth of axonal injury and repair after stroke.

Authors:  Jason D Hinman
Journal:  Curr Opin Neurol       Date:  2014-12       Impact factor: 5.710

4.  The Roles of Microtubules and Membrane Tension in Axonal Beading, Retraction, and Atrophy.

Authors:  Anagha Datar; Jaishabanu Ameeramja; Alka Bhat; Roli Srivastava; Ashish Mishra; Roberto Bernal; Jacques Prost; Andrew Callan-Jones; Pramod A Pullarkat
Journal:  Biophys J       Date:  2019-08-02       Impact factor: 4.033

Review 5.  Traumatic brain injury: cause or risk of Alzheimer's disease? A review of experimental studies.

Authors:  J Szczygielski; A Mautes; W I Steudel; P Falkai; T A Bayer; O Wirths
Journal:  J Neural Transm (Vienna)       Date:  2005-06-15       Impact factor: 3.575

6.  Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease.

Authors:  G W Roberts; S M Gentleman; A Lynch; L Murray; M Landon; D I Graham
Journal:  J Neurol Neurosurg Psychiatry       Date:  1994-04       Impact factor: 10.154

7.  Bundles of amyloid precursor protein-immunoreactive axons in human cerebrovascular white matter lesions.

Authors:  T Suenaga; K Ohnishi; M Nishimura; S Nakamura; I Akiguchi; J Kimura
Journal:  Acta Neuropathol       Date:  1994       Impact factor: 17.088

8.  Marked increase of beta-amyloid(1-42) and amyloid precursor protein in ventricular cerebrospinal fluid after severe traumatic brain injury.

Authors:  Annika Olsson; Ludvig Csajbok; Martin Ost; Kina Höglund; Karin Nylén; Lars Rosengren; Bengt Nellgård; Kaj Blennow
Journal:  J Neurol       Date:  2004-07       Impact factor: 4.849

Review 9.  Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease.

Authors:  Elena Anahi Bignante; Florencia Heredia; Gerardo Morfini; Alfredo Lorenzo
Journal:  Neurobiol Aging       Date:  2013-05-25       Impact factor: 4.673

10.  The distribution of amyloid beta precursor protein in canine brain.

Authors:  R Okuda; K Uchida; S Tateyama; R Yamaguchi; H Nakayama; N Goto
Journal:  Acta Neuropathol       Date:  1994       Impact factor: 17.088
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