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Literature DB >> 16356597

Immunogenicity of a single dose of reduced-antigen acellular pertussis vaccine in a non-vaccinated adolescent population.

Markus Knuf¹, Fred Zepp, Claudius Meyer, Edith Grzegowski, Joanne Wolter, Marion Riffelmann, Carl Heinz Wirsing von König.

Abstract

German adolescents (n=123) without previous pertussis vaccination, no history of pertussis and low IgG-anti-pertussis-toxin (PT) levels received one dose of the Tdap vaccine Boostrix. Blood samples were taken before, and 5-12 days and 29-49 days after vaccination. IgG- and IgA-anti-PT, IgG- and IgA-anti filamentous hemagglutinin, IgG-anti-pertactin, IgG-anti-tetanus-toxin, and IgG-anti-diphtheria-toxin were measured by ELISA. 88.6% of subjects had an immune response to PT, and all vaccinees had an immune response to at least one pertussis antigen 29-49 days after vaccination. IgA-anti-PT and IgA-anti-FHA responses were found in 43 and 81% of subjects, respectively. This study shows that in unvaccinated German adolescents pertussis immunity can be achieved by a single dose of Tdap.

Entities: Chemical

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Year: 2005 PMID： 16356597 DOI： 10.1016/j.vaccine.2005.11.024

Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641

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Cited

14 in total

1. Measuring immunoglobulin g antibodies to tetanus toxin, diphtheria toxin, and pertussis toxin with single-antigen enzyme-linked immunosorbent assays and a bead-based multiplex assay.

Authors: Sabine Reder; Marion Riffelmann; Christian Becker; Carl Heinz Wirsing von König
Journal: Clin Vaccine Immunol Date: 2008-03-05

2. Immunization of teenagers with a fifth dose of reduced DTaP-IPV induces high levels of pertussis antibodies with a significant increase in opsonophagocytic activity.

Authors: Audun Aase; Tove Karin Herstad; Samuel Merino; Merete Bolstad; Synne Sandbu; Hilde Bakke; Ingeborg S Aaberge
Journal: Clin Vaccine Immunol Date: 2011-06-15

Review 3. [Vaccination in adults].

Authors: D M Kieninger-Baum; F Zepp
Journal: Internist (Berl) Date: 2011-03 Impact factor: 0.743

4. Toward a new vaccine for pertussis.

Authors: John B Robbins; Rachel Schneerson; Joanna Kubler-Kielb; Jerry M Keith; Birger Trollfors; Evgeny Vinogradov; Joseph Shiloach
Journal: Proc Natl Acad Sci U S A Date: 2014-02-20 Impact factor: 11.205

Review 5. Reduced-antigen, combined diphtheria, tetanus and acellular pertussis vaccine, adsorbed (Boostrix®): a review of its properties and use as a single-dose booster immunization.

Authors: Paul L McCormack
Journal: Drugs Date: 2012-09-10 Impact factor: 9.546

Immunogenicity of a single dose of reduced-antigen acellular pertussis vaccine in a non-vaccinated adolescent population.

1. Measuring immunoglobulin g antibodies to tetanus toxin, diphtheria toxin, and pertussis toxin with single-antigen enzyme-linked immunosorbent assays and a bead-based multiplex assay.

2. Immunization of teenagers with a fifth dose of reduced DTaP-IPV induces high levels of pertussis antibodies with a significant increase in opsonophagocytic activity.

Review 3. [Vaccination in adults].

4. Toward a new vaccine for pertussis.

Review 5. Reduced-antigen, combined diphtheria, tetanus and acellular pertussis vaccine, adsorbed (Boostrix®): a review of its properties and use as a single-dose booster immunization.

6. Performance of commercial enzyme-linked immunosorbent assays for detection of antibodies to Bordetella pertussis.

Review 7. Pertussis: Microbiology, Disease, Treatment, and Prevention.

8. Pertussis: not only a disease of childhood.

9. Pertussis serology: assessment of IgG anti-PT ELISA for replacement of the CHO cell assay.

10. ERRATA CORRIGE.