| Literature DB >> 16356594 |
Arun Kumar1, Sanjay Babu Katiyar, Suman Gupta, Prem M S Chauhan.
Abstract
A series of triazino tetrahydroisoquinolines (3-5) and beta-carboline derivatives (15-27) have been synthesized as novel antileishmanial agents. Among them, compounds 15, 16 and 25 have shown 78.0%, 78.6% and 68.0% in vivo inhibition against Leishmania donovani at a dose of 50 mg kg(-1) x 5 days, respectively, while compounds 3 and 18 exhibited 55.6% and 53.3% in vivo inhibitions, respectively, against L. donovani at a dose of 50 mg kg(-1) x 5 days.Entities:
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Year: 2005 PMID： 16356594 DOI： 10.1016/j.ejmech.2005.09.007
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514