OBJECTIVE: To determine differences in case fatality rates between children with and without Down syndrome. STUDY DESIGN: We used the Pediatric Health Information System (PHIS) database, which includes demographic and diagnostic data from freestanding children's hospitals. Using Poisson regression, we determined the risk of mortality from sepsis for children with Down syndrome, after controlling for potential confounding factors. RESULTS: A total of 35,645 patients met our inclusion criteria, of which 3936 (11%) died during hospitalization. Altogether, 620 of the included patients also had a diagnosis of Down syndrome; 106 (17%) of these died during hospitalization. Children with Down syndrome had significantly elevated risk of mortality (mortality rate ratio = 1.30; 95% confidence interval = 1.06 to 1.59) after adjusting for potential confounding factors including demographics, pathogens, and concomitant conditions. CONCLUSIONS: Children with Down syndrome and sepsis have elevated risk of mortality. These findings have implications for treatment decisions, communications about prognosis, and future research.
OBJECTIVE: To determine differences in case fatality rates between children with and without Down syndrome. STUDY DESIGN: We used the Pediatric Health Information System (PHIS) database, which includes demographic and diagnostic data from freestanding children's hospitals. Using Poisson regression, we determined the risk of mortality from sepsis for children with Down syndrome, after controlling for potential confounding factors. RESULTS: A total of 35,645 patients met our inclusion criteria, of which 3936 (11%) died during hospitalization. Altogether, 620 of the included patients also had a diagnosis of Down syndrome; 106 (17%) of these died during hospitalization. Children with Down syndrome had significantly elevated risk of mortality (mortality rate ratio = 1.30; 95% confidence interval = 1.06 to 1.59) after adjusting for potential confounding factors including demographics, pathogens, and concomitant conditions. CONCLUSIONS:Children with Down syndrome and sepsis have elevated risk of mortality. These findings have implications for treatment decisions, communications about prognosis, and future research.
Authors: Elizabeth G Salazar; Yimei Li; Brian T Fisher; Susan R Rheingold; Julie Fitzgerald; Alix E Seif; Yuan-Shung Huang; Rochelle Bagatell; Richard Aplenc Journal: Br J Haematol Date: 2016-05-10 Impact factor: 6.998
Authors: Katherine A Waugh; Paula Araya; Ahwan Pandey; Kimberly R Jordan; Keith P Smith; Ross E Granrath; Santosh Khanal; Eric T Butcher; Belinda Enriquez Estrada; Angela L Rachubinski; Jennifer A McWilliams; Ross Minter; Tiana Dimasi; Kelley L Colvin; Dmitry Baturin; Andrew T Pham; Matthew D Galbraith; Kyle W Bartsch; Michael E Yeager; Christopher C Porter; Kelly D Sullivan; Elena W Hsieh; Joaquin M Espinosa Journal: Cell Rep Date: 2019-11-12 Impact factor: 9.423
Authors: F P Pellegrini; M Marinoni; V Frangione; A Tedeschi; V Gandini; F Ciglia; L Mortara; R S Accolla; L Nespoli Journal: Clin Exp Immunol Date: 2012-09 Impact factor: 4.330
Authors: Shane M Tibby; Andrew Durward; Chong Tien Goh; Kentigern Thorburn; Kevin Morris; Mike Broadhead; Mark J Peters Journal: Intensive Care Med Date: 2012-05-15 Impact factor: 17.440