| Literature DB >> 16355448 |
Hung-Che Shih1, Tzu-Hsin Lee, Shu-Chen Chen, Chien-Ying Li, Takeshi Shibuya.
Abstract
This research investigated the anti-hypertension effect of the traditional Chinese medicine (TCM) ju-ling-tang (JLT) on an animal model of hypertension induced by unilateral renal artery ligation. In the study of anti-hypertension effects, 60 minutes after oral administration with NG tube feeding of 240 mg/kg JLT, a significant decrease in blood pressure (p < 0.05) was observed and sustained till 120 minutes. In the group given 50 mg/kg alpha-methyldopa orally, the effect was obvious 90 minutes after medication (p < 0.01), and lasted until 240 minutes. In terms of organ pathology, a significant reduction in the extent of induced glomerular sclerosis was observed in rats given 240 mg/kg JLT compared with the control. From these results, we infer that JLT has a beneficial anti-hypertensive effect on renal hypertension.Entities:
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Year: 2005 PMID： 16355448 DOI： 10.1142/S0192415X05003545
Source DB: PubMed Journal: Am J Chin Med ISSN： 0192-415X Impact factor: 4.667