Literature DB >> 16353277

New synthetic thiocolchicine derivatives as lowtoxic anticancer agents.

Sun-Hee Lee1, Sun-Kyoung Park, Jeong-Mi Kim, Myung-Hwa Kim, Kwang-Hee Kim, Kwang-Woo Chun, Kyung-Hea Cho, Ji-Youn Youn, Sung Keon Namgoong.   

Abstract

New thiocolchicine derivatives (1-8) were designed as less toxic anticancer agents possessing the power full anticancer activity of colchicine. The synthesis and biological evaluation of these compounds were described. As a preliminary result of biological in vitro investigation, compounds 1, 6, and 7 showed lower toxicities than that of colchicine in combination with potent anticancer activities.

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Year:  2005        PMID： 16353277     DOI： 10.1002/ardp.200500148

Source DB:  PubMed          Journal:  Arch Pharm (Weinheim)        ISSN： 0365-6233            Impact factor:   3.751


  6 in total

1.  Design, Synthesis, and Antitumor Activity of 4-Halocolchicines and Their Pro-drugs Activated by Cathepsin B.

Authors:  Naoko Yasobu; Mariko Kitajima; Noriyuki Kogure; Yoshiyuki Shishido; Takeshi Matsuzaki; Masato Nagaoka; Hiromitsu Takayama
Journal:  ACS Med Chem Lett       Date:  2011-03-04       Impact factor: 4.345

2.  A novel colchicine-based microtubule inhibitor exhibits potent antitumor activity by inducing mitochondrial mediated apoptosis in MIA PaCa-2 pancreatic cancer cells.

Authors:  Ashok Kumar; Baljinder Singh; Girish Mahajan; Parduman R Sharma; Sandip B Bharate; Mubashir J Mintoo; Dilip M Mondhe
Journal:  Tumour Biol       Date:  2016-07-24

3.  7-Deacetyl-10-alkylthiocolchicine derivatives - new compounds with potent anticancer and fungicidal activity.

Authors:  Joanna Kurek; Patrycja Kwaśniewska-Sip; Krzysztof Myszkowski; Grzegorz Cofta; Marek Murias; Piotr Barczyński; Beata Jasiewicz; Rafał Kurczab
Journal:  Medchemcomm       Date:  2018-08-16       Impact factor: 3.597

4.  A Novel Microtubule-Disrupting Agent Induces Endoplasmic Reticular Stress-Mediated Cell Death in Human Hepatocellular Carcinoma Cells.

Authors:  Chun-Te Ho; Yu-Jia Chang; Li-Xi Yang; Po-Li Wei; Tsan-Zon Liu; Jun-Jen Liu
Journal:  PLoS One       Date:  2015-09-10       Impact factor: 3.240

5.  Synthesis, Antiproliferative Activity and Molecular Docking Studies of Novel Doubly Modified Colchicine Amides and Sulfonamides as Anticancer Agents.

Authors:  Julia Krzywik; Witold Mozga; Maral Aminpour; Jan Janczak; Ewa Maj; Joanna Wietrzyk; Jack A Tuszyński; Adam Huczyński
Journal:  Molecules       Date:  2020-04-14       Impact factor: 4.411

6.  New Series of Double-Modified Colchicine Derivatives: Synthesis, Cytotoxic Effect and Molecular Docking.

Authors:  Julia Krzywik; Maral Aminpour; Ewa Maj; Witold Mozga; Joanna Wietrzyk; Jack A Tuszyński; Adam Huczyński
Journal:  Molecules       Date:  2020-08-02       Impact factor: 4.411
  6 in total

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