Literature DB >> 16352713

Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs.

Desheng Lu1, Howard B Cottam, Maripat Corr, Dennis A Carson.   

Abstract

Activation of the Wnt/beta-catenin pathway promotes the development of several cancers and is an attractive target for chemopreventive and chemotherapeutic agents. Nonsteroidal antiinflammatory drugs (NSAIDs) have been reported to antagonize beta-catenin function, but their mechanism of action is not known. We demonstrate here that interference with beta-catenin function by NSAIDs does not correlate with cyclooxygenase (COX) inhibition. Instead, NSAID inhibition of beta-catenin requires the high level expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma) and its co-receptor retinoid-X-receptor alpha (RXR-alpha). Immunoprecipitation experiments show that beta-catenin interacts with RXR-alpha and PPAR-gamma in some malignant cells. Repression of beta-catenin-dependent transcription by NSAIDs is thus indirect and depends on the coexpression of other nuclear receptors.

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Year:  2005        PMID： 16352713      PMCID： PMC1317972          DOI： 10.1073/pnas.0509316102

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  59 in total

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Authors:  Gillian Hawcroft; Mark D'Amico; Chris Albanese; Alexander F Markham; Richard G Pestell; Mark A Hull
Journal:  Carcinogenesis       Date:  2002-01       Impact factor: 4.944

4.  Inhibition of beta-catenin translocation in rodent colorectal tumors: a novel explanation for the protective effect of nonsteroidal antiinflammatory drugs in colorectal cancer.

Authors:  W A Brown; S A Skinner; D Vogiagis; P E O'Brien
Journal:  Dig Dis Sci       Date:  2001-11       Impact factor: 3.199

5.  Effect of anti-inflammatory drugs on overall risk of common cancer: case-control study in general practice research database.

Authors:  M J Langman; K K Cheng; E A Gilman; R J Lancashire
Journal:  BMJ       Date:  2000-06-17

6.  The NFAT-related protein NFATL1 (TonEBP/NFAT5) is induced upon T cell activation in a calcineurin-dependent manner.

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Authors:  Susanne Dihlmann; Simone Klein; Magnus von Knebel Doeberitz Mv
Journal:  Mol Cancer Ther       Date:  2003-06       Impact factor: 6.261

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10.  Breast cancer and NSAID use: a meta-analysis.

Authors:  S A Khuder; A B Mutgi
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  33 in total

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Authors:  Marcia I Dawson; Zebin Xia
Journal:  Biochim Biophys Acta       Date:  2011-10-01

Review 2.  Molecular basis of the potential of mesalazine to prevent colorectal cancer.

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Journal:  World J Gastroenterol       Date:  2008-07-28       Impact factor: 5.742

3.  HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression.

Authors:  Y Li; J H Bavarva; Z Wang; J Guo; C Qian; S N Thibodeau; E A Golemis; W Liu
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Journal:  PPAR Res       Date:  2009-07-07       Impact factor: 4.964

6.  Sulindac suppresses beta-catenin expression in human cancer cells.

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Journal:  Eur J Pharmacol       Date:  2008-02-05       Impact factor: 4.432

7.  PPARgamma and Wnt/beta-Catenin pathway in human breast cancer: expression pattern, molecular interaction and clinical/prognostic correlations.

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8.  Distinct patterns of ALDH1A1 expression predict metastasis and poor outcome of colorectal carcinoma.

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9.  Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway.

Authors:  Desheng Lu; Dennis A Carson
Journal:  BMC Pharmacol       Date:  2009-11-30

10.  Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway.

Authors:  Desheng Lu; Jerry X Liu; Tomoyuki Endo; Haowen Zhou; Shiyin Yao; Karl Willert; Ingo G H Schmidt-Wolf; Thomas J Kipps; Dennis A Carson
Journal:  PLoS One       Date:  2009-12-14       Impact factor: 3.240
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