BACKGROUND: Diabetes in humans induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy and polyneuropathy. The most common animal model of human diabetes is streptozotocin (STZ)-induced diabetes in the rat. METHODS: This project assessed cardiovascular, ocular and neuropathic changes over a period of 24 weeks post STZ administration in rats. RESULTS: STZ-diabetic rats (n = 96) showed stable signs of diabetes (hyperglycaemia, increased water and food intake with no increase in bodyweight): 52% of untreated STZ-diabetic rats (n = 50) survived 24 weeks after STZ administration. STZ-diabetic rats were normotensive with slowly developing systolic and diastolic dysfunction and an increased ventricular stiffness. Ventricular action potential durations were markedly prolonged. STZ-diabetic rats developed stable tactile allodynia. Cataracts developed to presumed blindness at 16 weeks but proliferative retinopathy was not observed even after 24 weeks. CONCLUSION: The chronic STZ-diabetic rat mimics many but not all of the chronic complications observed in the diabetic human. The chronic STZ-diabetic rat may be a useful model to test therapeutic approaches for amelioration of chronic diabetic complications in humans.
BACKGROUND:Diabetes in humans induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy and polyneuropathy. The most common animal model of humandiabetes is streptozotocin (STZ)-induced diabetes in the rat. METHODS: This project assessed cardiovascular, ocular and neuropathic changes over a period of 24 weeks post STZ administration in rats. RESULTS:STZ-diabeticrats (n = 96) showed stable signs of diabetes (hyperglycaemia, increased water and food intake with no increase in bodyweight): 52% of untreated STZ-diabeticrats (n = 50) survived 24 weeks after STZ administration. STZ-diabeticrats were normotensive with slowly developing systolic and diastolic dysfunction and an increased ventricular stiffness. Ventricular action potential durations were markedly prolonged. STZ-diabeticrats developed stable tactile allodynia. Cataracts developed to presumed blindness at 16 weeks but proliferative retinopathy was not observed even after 24 weeks. CONCLUSION: The chronic STZ-diabeticrat mimics many but not all of the chronic complications observed in the diabetichuman. The chronic STZ-diabeticrat may be a useful model to test therapeutic approaches for amelioration of chronic diabetic complications in humans.
Authors: Diego C Fernandez; Pablo H Sande; Mónica S Chianelli; Hernán J Aldana Marcos; Ruth E Rosenstein Journal: Am J Pathol Date: 2011-05 Impact factor: 4.307
Authors: F C Howarth; M A Qureshi; Z Hassan; D Isaev; K Parekh; A John; M Oz; H Raza; E Adeghate; T E Adrian Journal: Mol Cell Biochem Date: 2011-10-19 Impact factor: 3.396
Authors: Laura E O'Dell; Luis A Natividad; Joseph A Pipkin; Francisco Roman; Ivan Torres; Jesus Jurado; Oscar V Torres; Theodore C Friedman; John M Tenayuca; Arbi Nazarian Journal: Addict Biol Date: 2013-07-08 Impact factor: 4.280
Authors: Bryan Cruz; Rodolfo J Flores; Kevin P Uribe; Evangelina J Espinoza; Charles T Spencer; Katherine M Serafine; Arbi Nazarian; Laura E O'Dell Journal: Neuropsychopharmacology Date: 2019-01-07 Impact factor: 7.853