BACKGROUND: Echocardiography is used in humans to characterise the structure and function of the heart, yet is relatively uncommon in studies on the rat, the most commonly used model of human cardiovascular disease. The aim of this study was to show that echocardiography in rats provides useful information on cardiac changes occurring in thyroid dysfunction and can also be used to characterise cardiac abnormalities. METHODS: Transthoracic echocardiography and Doppler techniques with high frequency, high frame rate imaging were used to define cardiac dimensions and function in 240 Wistar rats and cardiac abnormalities in Wistar and spontaneously hypertensive rats (SHR). RESULTS: Echocardiographic assessment of left ventricular dimensions and function and aortic flows was technically feasible in almost all adult Wistar rats and SHR, including those with thyroid dysfunction and cardiac abnormalities. Pulsed-wave Doppler profiles of mitral inflows to estimate diastolic function were less reliably obtained. CONCLUSIONS: Echocardiography is a powerful technique for non-invasive and serial determination of cardiac structure and function in rat models of human cardiovascular disease.
BACKGROUND: Echocardiography is used in humans to characterise the structure and function of the heart, yet is relatively uncommon in studies on the rat, the most commonly used model of humancardiovascular disease. The aim of this study was to show that echocardiography in rats provides useful information on cardiac changes occurring in thyroid dysfunction and can also be used to characterise cardiac abnormalities. METHODS: Transthoracic echocardiography and Doppler techniques with high frequency, high frame rate imaging were used to define cardiac dimensions and function in 240 Wistar rats and cardiac abnormalities in Wistar and spontaneously hypertensiverats (SHR). RESULTS: Echocardiographic assessment of left ventricular dimensions and function and aortic flows was technically feasible in almost all adult Wistar rats and SHR, including those with thyroid dysfunction and cardiac abnormalities. Pulsed-wave Doppler profiles of mitral inflows to estimate diastolic function were less reliably obtained. CONCLUSIONS: Echocardiography is a powerful technique for non-invasive and serial determination of cardiac structure and function in rat models of humancardiovascular disease.
Authors: Vladislava Zohdi; James T Pearson; Michelle M Kett; Paul Lombardo; Michal Schneider; M Jane Black Journal: Eur J Nutr Date: 2014-08-13 Impact factor: 5.614
Authors: J Raymond Fitzpatrick; John R Frederick; Ryan C McCormick; David A Harris; Ah-Young Kim; Jeffrey R Muenzer; Alex J Gambogi; Jing Ping Liu; E Carter Paulson; Y Joseph Woo Journal: J Thorac Cardiovasc Surg Date: 2010-04-03 Impact factor: 5.209
Authors: Vítor Scotta Hentschke; Lucas Capalonga; Douglas Dalcin Rossato; Júlia Luíza Perini; Jadson Pereira Alves; Giuseppe Potrick Stefani; Marlus Karsten; Mauro Pontes; Pedro Dal Lago Journal: Lasers Med Sci Date: 2016-11-17 Impact factor: 3.161
Authors: John R Frederick; J Raymond Fitzpatrick; Ryan C McCormick; David A Harris; Ah-Young Kim; Jeffrey R Muenzer; Nicole Marotta; Maximilian J Smith; Jeffrey E Cohen; William Hiesinger; Pavan Atluri; Y Joseph Woo Journal: Circulation Date: 2010-09-14 Impact factor: 29.690
Authors: John W MacArthur; Alen Trubelja; Yasuhiro Shudo; Philip Hsiao; Alexander S Fairman; Elaine Yang; William Hiesinger; Joseph J Sarver; Pavan Atluri; Y Joseph Woo Journal: J Thorac Cardiovasc Surg Date: 2013-01 Impact factor: 5.209
Authors: Thao P Nguyen; Ali A Sovari; Arash Pezhouman; Shankar Iyer; Hong Cao; Christopher Y Ko; Aneesh Bapat; Nooshin Vahdani; Mostafa Ghanim; Michael C Fishbein; Hrayr S Karagueuzian Journal: J Physiol Date: 2016-01-18 Impact factor: 5.182
Authors: John W MacArthur; Brendan P Purcell; Yasuhiro Shudo; Jeffrey E Cohen; Alex Fairman; Alen Trubelja; Jay Patel; Philip Hsiao; Elaine Yang; Kelsey Lloyd; William Hiesinger; Pavan Atluri; Jason A Burdick; Y Joseph Woo Journal: Circulation Date: 2013-09-10 Impact factor: 29.690