| Literature DB >> 163493 |
B I Posner, P A Kelly, H G Friesen.
Abstract
A prolactin receptor, present in adult female rat liver, can be induced in males by estrogen. Hypophysectomy diminished receptor levels in the female and rendered males unresponsive to estrogen. A renal pituitary implant blunted the decrease in hypophysectomized females and induced the receptor in hyophysectomized males. The increased receptor level in hypophysectomized males with a renal pituitary implant was preceded by a sustained elevation of circulating prolactin. Our observations suggest that prolactin induces its own receptor.Entities:
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Year: 1975 PMID: 163493 DOI: 10.1126/science.163493
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728