Literature DB >> 163492

Insulin-induced augmentation of lymphocyte-mediated cytotoxicity.

T B Strom, R A Bear, C B Carpenter.   

Abstract

Physiologic concentrations of insulin enhance the ability of cytotoxic lymphocytes to injure target cells. The effect of insulin closely resembles the action of cholinomimetics and guanosine 3',5'-monophosphate upon this system. Since both insulin and cholinomimetics elevate intracellular concentrations of guanosine 3',5'-monophosphate, a common mode of action is suggested.

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Year:  1975        PMID: 163492     DOI: 10.1126/science.163492

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  18 in total

1.  Immune responses of diabetic animals. Direct immunosuppressant effects of streptozotocin in mice.

Authors:  W K Nichols; J B Spellman; L L Vann; R A Daynes
Journal:  Diabetologia       Date:  1979-01       Impact factor: 10.122

2.  2006 Homer W. Smith Lecture: taming T cells.

Authors:  Terry B Strom
Journal:  J Am Soc Nephrol       Date:  2007-10-17       Impact factor: 10.121

3.  Enhancement of "one-way" human mixed lymphocyte reaction by cholinergic agents.

Authors:  T Han
Journal:  Clin Exp Immunol       Date:  1976-08       Impact factor: 4.330

4.  Specific insulin binding site on T and B lymphocytes as a marker of cell activation.

Authors:  J H Helderman; T B Strom
Journal:  Nature       Date:  1978-07-06       Impact factor: 49.962

5.  Effect of insulin on the expression of interleukin 2 receptor.

Authors:  Z H Feng; Y Luo; R D Wang; Z C Chen
Journal:  J Tongji Med Univ       Date:  1988

Review 6.  Multiple immunological abnormalities in patients with type 1 (insulin-dependent) diabetes mellitus.

Authors:  D W Drell; A L Notkins
Journal:  Diabetologia       Date:  1987-03       Impact factor: 10.122

7.  Emergence of insulin receptors upon alloimmune T cells in the rat.

Authors:  J H Helderman; T B Strom
Journal:  J Clin Invest       Date:  1977-02       Impact factor: 14.808

8.  Immune response in the mutant diabetic C57BL/Ks-dt+ mouse. Discrepancies between in vitro and in vivo immunological assays.

Authors:  G Fernandes; B S Handwerger; E J Yunis; D M Brown
Journal:  J Clin Invest       Date:  1978-02       Impact factor: 14.808

9.  Impaired antibody responses in alloxan diabetic mice.

Authors:  W Ptak; M Hanczakowska; R Rózycka; D Rózycka
Journal:  Clin Exp Immunol       Date:  1977-07       Impact factor: 4.330

10.  Effect of insulin on immunological phagocytosis by macrophages.

Authors:  A O Lima; M Queiroz; H M Bräscher; J Vargens
Journal:  Experientia       Date:  1979-01-15
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