| Literature DB >> 163491 |
Abstract
Guanosine 3',5'-monophosphate (cyclic GMP) and cholinergic agents stimulate incorporation of phosphate into specific nuclear acidic proteins of horse peripheral blood lymphocytes. Agents that raise intracellular adenosine 3',5'-monophosphate (cyclic AMP) inhibit nuclear acidic protein phosphorylation. The opposing effects of cyclic GMP and cyclic AMP upon nuclear protein phosphorylation parallel the effects of the cyclic nucleotides upon induction of lymphocyte proliferation.Entities:
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Year: 1975 PMID: 163491 DOI: 10.1126/science.163491
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728