OBJECTIVE: To examine the impact of childhood body mass index (BMI) on timing of puberty, adult stature and obesity. DESIGN: A retrospective school-based cohort follow-up study. SUBJECTS: A total of 1520 men born between 1927 and 1956 with serial height and weight measurements from the age of 9 to 18, followed up in adulthood at a mean age of 63 years. MEASUREMENTS: Prepubertal (child) BMI; age at peak height velocity (APHV); adult leg length, waist and hip circumference (self-reported), and height and weight (measured). RESULTS: Boys with a higher childhood BMI tended to have an earlier puberty (per s.d. increase in child BMI: -0.31 years, 95% confidence interval (CI): -0.23 to -0.39, P < 0.001). Childhood BMI correlated strongly and positively with adult adiposity, as measured by BMI (1.24 kg/m(2), 95% CI: 1.04-1.45, P < 0.001), waist (1.94 cm, 95% CI: 1.50-2.37, P < 0.001) and hip (1.91 cm, 95% CI: 1.55-2.28, P < 0.001). It correlated inversely with leg length (-0.40 cm, 95% CI: -0.68 to -0.12, P = 0.005), but not significantly with height or trunk length. Boys with a later puberty tended to be taller (per s.d. increase in APHV: 0.57 cm, 95% CI: 0.17-0.97, P = 0.006) and less adipose as adults (-0.55 kg/m(2), 95% CI: -0.33 to -0.77, P < 0.001). CONCLUSION: The long-term consequences of childhood obesity into adulthood are well known, but the potential impact on early pubertal maturation is less well appreciated. The factors that contribute to the onset and persistence of childhood obesity require more public health focus.
OBJECTIVE: To examine the impact of childhood body mass index (BMI) on timing of puberty, adult stature and obesity. DESIGN: A retrospective school-based cohort follow-up study. SUBJECTS: A total of 1520 men born between 1927 and 1956 with serial height and weight measurements from the age of 9 to 18, followed up in adulthood at a mean age of 63 years. MEASUREMENTS: Prepubertal (child) BMI; age at peak height velocity (APHV); adult leg length, waist and hip circumference (self-reported), and height and weight (measured). RESULTS: Boys with a higher childhood BMI tended to have an earlier puberty (per s.d. increase in child BMI: -0.31 years, 95% confidence interval (CI): -0.23 to -0.39, P < 0.001). Childhood BMI correlated strongly and positively with adult adiposity, as measured by BMI (1.24 kg/m(2), 95% CI: 1.04-1.45, P < 0.001), waist (1.94 cm, 95% CI: 1.50-2.37, P < 0.001) and hip (1.91 cm, 95% CI: 1.55-2.28, P < 0.001). It correlated inversely with leg length (-0.40 cm, 95% CI: -0.68 to -0.12, P = 0.005), but not significantly with height or trunk length. Boys with a later puberty tended to be taller (per s.d. increase in APHV: 0.57 cm, 95% CI: 0.17-0.97, P = 0.006) and less adipose as adults (-0.55 kg/m(2), 95% CI: -0.33 to -0.77, P < 0.001). CONCLUSION: The long-term consequences of childhood obesity into adulthood are well known, but the potential impact on early pubertal maturation is less well appreciated. The factors that contribute to the onset and persistence of childhood obesity require more public health focus.
Authors: Elisabeth Widén; Samuli Ripatti; Diana L Cousminer; Ida Surakka; Tuuli Lappalainen; Marjo-Riitta Järvelin; Johan G Eriksson; Olli Raitakari; Veikko Salomaa; Ulla Sovio; Anna-Liisa Hartikainen; Anneli Pouta; Mark I McCarthy; Clive Osmond; Eero Kajantie; Terho Lehtimäki; Jorma Viikari; Mika Kähönen; Chris Tyler-Smith; Nelson Freimer; Joel N Hirschhorn; Leena Peltonen; Aarno Palotie Journal: Am J Hum Genet Date: 2010-04-15 Impact factor: 11.025
Authors: Corinna Koebnick; Ning Smith; Mary Helen Black; Amy H Porter; Bradley A Richie; Sharon Hudson; Deborah Gililland; Steven J Jacobsen; George F Longstreth Journal: J Pediatr Gastroenterol Nutr Date: 2012-09 Impact factor: 2.839
Authors: J C Lo; B Maring; M Chandra; S R Daniels; A Sinaiko; M F Daley; N E Sherwood; E O Kharbanda; E D Parker; K F Adams; R J Prineas; D J Magid; P J O'Connor; L C Greenspan Journal: Pediatr Obes Date: 2013-05-15 Impact factor: 4.000
Authors: Izzuddin M Aris; Sheryl L Rifas-Shiman; Xun Zhang; Seungmi Yang; Karen Switkowski; Abby F Fleisch; Marie-France Hivert; Richard M Martin; Michael S Kramer; Emily Oken Journal: Obesity (Silver Spring) Date: 2019-09-03 Impact factor: 5.002