| Literature DB >> 16343898 |
Julieta Coro1, Richard Atherton, Susan Little, Hayley Wharton, Vanessa Yardley, Amaury Alvarez, Margarita Súarez, Rolando Pérez, Hortensia Rodríguez.
Abstract
The effect of several alkyl-linked bis tetrahydro-(2H)-1,3,5-thiadiazine-2-thione (bis-THTT) on Leishmania donovani, Trypanosoma brucei rhodesiense, and Plasmodium falciparum is reported. Most of the compounds exhibited a potent activity against the three parasitic strains but the best in vitro activity profiles were found against T. b. rhodesiense with IC(50) values ranging between 0.3 and 4 microM for the most active compounds.Entities:
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Year: 2005 PMID： 16343898 DOI： 10.1016/j.bmcl.2005.11.060
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823