Literature DB >> 16341932

Is the platelet serotonin transporter different in venous vs. arterial blood?

Emiliano Villa1, Claudio Albano, Andrea Cappelli, Emilio Favale, Emilia Fugassa, Ezio Gerdoni, Simona Scarrone, Aroldo Cupello.   

Abstract

The binding of labelled paroxetine to the serotonin transporter (SERT) of platelet membranes has been studied in both venous and mixed venous/arterial blood of the rat. In addition, we studied the inhibition of paroxetine binding to SERT by quipazine and N-methyl-quipazine (NMQ). The results indicate differences in affinity for the two test drugs, quipazine and NMQ, in venous vs. mixed venous/arterial blood. This suggests different post-translational modifications of SERT in platelets of arterial vs. venous blood.

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Year:  2005        PMID： 16341932     DOI： 10.1007/s11064-005-8342-x

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  15 in total

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Journal:  Bioorg Med Chem       Date:  2005-05-16       Impact factor: 3.641

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  1 in total

1.  Binding of paroxetine to the serotonin transporter in membranes from different cells, subcellular fractions and species.

Authors:  A Cupello; C Albano; E Gatta; S Scarrone; E Villa; G Zona
Journal:  Neurochem Res       Date:  2008-06-18       Impact factor: 3.996
  1 in total

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