Literature DB >> 16341789

A new fluorescent assay for enalapril maleate.

María de los A Oliva1, Lorena L Sombra, Roberto A Olsina, Adriana N Masi.   

Abstract

A new spectrofluorimetric method for the enalapril maleate monitoring was studied. Enalapril maleate was found to be highly photolabile. This drug was evaluated according to photodegradation assay at pH 2.5 and 6. Enalapril maleate was exposed to UVA-UVB radiations. Under these specific conditions was found as degradation product, the diketopiperazine. The modification of the fluorescent properties of enalapril maleate in solution after exposure UV-radiation and the degradation mechanisms were studied. The photodegradation was followed by the developed spectrofluorimetric assay.

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Year:  2005        PMID： 16341789     DOI： 10.1007/s10895-005-2979-3

Source DB:  PubMed          Journal:  J Fluoresc        ISSN： 1053-0509            Impact factor:   2.217


  4 in total

1.  Evaluation of stability of enalapril maleate in solid phase.

Authors:  Beata Stanisz
Journal:  J Pharm Biomed Anal       Date:  2003-02-26       Impact factor: 3.935

2.  Reaction kinetics of solid-state cyclization of enalapril maleate investigated by isothermal FT-IR microscopic system.

Authors:  S L Wang; S Y Lin; T F Chen
Journal:  Chem Pharm Bull (Tokyo)       Date:  2001-04       Impact factor: 1.645

3.  Effect of the drug-matrix on the stability of enalapril maleate in tablet formulations.

Authors:  M M Al-Omari; M K Abdelah; A A Badwan; A M Jaber
Journal:  J Pharm Biomed Anal       Date:  2001-07       Impact factor: 3.935

4.  Effect of column temperature on the behaviour of some angiotensin converting enzyme inhibitors during high-performance liquid chromatographic analysis.

Authors:  A Kocijan; R Grahek; D Kocjan; L Zupancic-Kralj
Journal:  J Chromatogr B Biomed Sci Appl       Date:  2001-05-05
  4 in total

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