M A T Muftuoglu1, S Isikgor, S Tosun, A Saglam. 1. The Fourth General Surgical Department of Haydarpasa Numune Teaching and Training Hospital, Uskudar, Istanbul, Turkey. tmuftuoglu@ttnet.net.tr
Abstract
OBJECTIVE: This study was designed to evaluate the effects of probiotics on the severity of experimental acute pancreatitis. DESIGN: Experimental study. SETTING: Experiments were done in a laboratory at Haydarpasa Numune Teaching and Research Hospital. SUBJECTS: A total of 50 Wistar rats were randomly divided into five groups. INTERVENTIONS: Group 1 was control group. Group 2 received an intraperitoneal injection of a 20% solution in 0.15 mol/l NaCL. Group 3 was injected NaCL and fed with probiotics. Acute pancreatitis was induced in rats by intrperitoneal injection of L-Arginine in groups 4 and 5. The rats in group 5 were treated with probiotics. The pancreas was removed for histologic examination. Evaluation of the pathologic changes was done by a new combined histopathologic grading scale. RESULTS: The mean scores of fibrosis, acinar cell loss, oedema, parenchymal necrosis, mononuclear cells infiltration, polymorphonuclear leucocytes infiltration, ductal damage and atypical reactive regeneration in group 5 were significantly lower than group 4. CONCLUSIONS: We demonstrated that enteral feedings with added probiotics can reduce the severity of acute pancreatitis. SPONSORSHIP: None.
OBJECTIVE: This study was designed to evaluate the effects of probiotics on the severity of experimental acute pancreatitis. DESIGN: Experimental study. SETTING: Experiments were done in a laboratory at Haydarpasa Numune Teaching and Research Hospital. SUBJECTS: A total of 50 Wistar rats were randomly divided into five groups. INTERVENTIONS: Group 1 was control group. Group 2 received an intraperitoneal injection of a 20% solution in 0.15 mol/l NaCL. Group 3 was injected NaCL and fed with probiotics. Acute pancreatitis was induced in rats by intrperitoneal injection of L-Arginine in groups 4 and 5. The rats in group 5 were treated with probiotics. The pancreas was removed for histologic examination. Evaluation of the pathologic changes was done by a new combined histopathologic grading scale. RESULTS: The mean scores of fibrosis, acinar cell loss, oedema, parenchymal necrosis, mononuclear cells infiltration, polymorphonuclear leucocytes infiltration, ductal damage and atypical reactive regeneration in group 5 were significantly lower than group 4. CONCLUSIONS: We demonstrated that enteral feedings with added probiotics can reduce the severity of acute pancreatitis. SPONSORSHIP: None.
Authors: Nara L Horst; Ruy Garcia Marques; Cristina F Diestel; Bianca D Matzke; Carlos Eduardo R Caetano; Fernanda Correia Simões; Arnaldo F B Andrade; Wagner I Lobão; Luiz Carlos A Vaz; Margareth C Portela; José Ueleres Braga; Paulo A Melo Journal: Curr Ther Res Clin Exp Date: 2009-04
Authors: Lindsay M Urben; Jennifer Wiedmar; Erica Boettcher; Rodrigo Cavallazzi; Robert G Martindale; Stephen A McClave Journal: Curr Gastroenterol Rep Date: 2014
Authors: Maisam Abu-El-Haija; Soma Kumar; Jose Antonio Quiros; Keshawadhana Balakrishnan; Bradley Barth; Samuel Bitton; John F Eisses; Elsie Jazmin Foglio; Victor Fox; Denease Francis; Alvin Jay Freeman; Tanja Gonska; Amit S Grover; Sohail Z Husain; Rakesh Kumar; Sameer Lapsia; Tom Lin; Quin Y Liu; Asim Maqbool; Zachary M Sellers; Flora Szabo; Aliye Uc; Steven L Werlin; Veronique D Morinville Journal: J Pediatr Gastroenterol Nutr Date: 2018-01 Impact factor: 2.839
Authors: Balázs Kui; Zsolt Balla; Eszter T Végh; Petra Pallagi; Viktória Venglovecz; Béla Iványi; Tamás Takács; Péter Hegyi; Zoltán Rakonczay Journal: Lab Invest Date: 2013-12-23 Impact factor: 5.662
Authors: Nada Rayes; Daniel Seehofer; Tom Theruvath; Martina Mogl; Jan M Langrehr; Natascha C Nüssler; Stig Bengmark; Peter Neuhaus Journal: Ann Surg Date: 2007-07 Impact factor: 12.969