OBJECTIVES: To evaluate the clinical applicability of the determination of disseminated intravascular coagulation (DIC) parameters in acute pancreatitis. METHODS: The subjects for this study were 139 consecutive patients with acute pancreatitis. DIC parameters were assessed at the initial observation of these patients. RESULTS: The levels of the DIC parameters at admission were significantly associated with the severity and the prognosis of acute pancreatitis. Antithrombin III (AT-III), fibrin/fibrinogen degradation products-E, platelet count, D-dimer, and thrombin-AT-III complex at admission showed better area under the receiver operating characteristics curve values compared with C-reactive protein. An AT-III value of 69% at admission was the best cut-off value to predict fatal outcome (sensitivity, 81%; specificity, 86%). CONCLUSIONS: The aggravated coagulation parameters predict a fatal outcome in patients with acute pancreatitis. AT-III level (<69%) was the most accurate marker for poor outcome of acute pancreatitis at admission.
OBJECTIVES: To evaluate the clinical applicability of the determination of disseminated intravascular coagulation (DIC) parameters in acute pancreatitis. METHODS: The subjects for this study were 139 consecutive patients with acute pancreatitis. DIC parameters were assessed at the initial observation of these patients. RESULTS: The levels of the DIC parameters at admission were significantly associated with the severity and the prognosis of acute pancreatitis. Antithrombin III (AT-III), fibrin/fibrinogen degradation products-E, platelet count, D-dimer, and thrombin-AT-III complex at admission showed better area under the receiver operating characteristics curve values compared with C-reactive protein. An AT-III value of 69% at admission was the best cut-off value to predict fatal outcome (sensitivity, 81%; specificity, 86%). CONCLUSIONS: The aggravated coagulation parameters predict a fatal outcome in patients with acute pancreatitis. AT-III level (<69%) was the most accurate marker for poor outcome of acute pancreatitis at admission.
Authors: Ellen Andersson; Jakob Axelsson; Gunilla Eckerwall; Daniel Ansari; Roland Andersson Journal: World J Gastroenterol Date: 2010-12-28 Impact factor: 5.742
Authors: Min-Jung Park; Sapna Iyer; Xiang Xue; Juliana Bragazzi Cunha; Shufang Gu; David Moons; Steven W Pipe; John A Williams; Diane M Simeone; Yatrik M Shah; M Bishr Omary Journal: Gastroenterology Date: 2018-02-01 Impact factor: 22.682
Authors: Daiki Okamura; Marlene E Starr; Eun Y Lee; Arnold J Stromberg; B Mark Evers; Hiroshi Saito Journal: Aging Cell Date: 2012-07-04 Impact factor: 9.304