Literature DB >> 16340311

Anaphase topsy-turvy: Cdk1 a securin, separase a CKI.

Olaf Stemmann1, Ingo H Gorr, Dominik Boos.   

Abstract

Chromosome segregation in mitosis and meiosis is triggered by activation of a large protease, separase. While it has been known for some time that the anaphase inhibitor securin regulates separase activity recent work shows that this is only half the story. In vertebrates Cdk1-dependent inhibition of separase represents a second, securin-independent branch of anaphase regulation. Furthermore, an unanticipated ability of separase to inhibit Cdk1 suggests additional, nonproteolytic functions of separase.

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Year:  2006        PMID： 16340311     DOI： 10.4161/cc.5.1.2296

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  13 in total

1.  Regulation of the final stage of mitosis by components of the pre-replicative complex and a polo kinase.

Authors:  Hyungshin Yim; Raymond L Erikson
Journal:  Cell Cycle       Date:  2011-05-01       Impact factor: 4.534

2.  Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase.

Authors:  Hyungshin Yim; Raymond L Erikson
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-01       Impact factor: 11.205

3.  PP2A delays APC/C-dependent degradation of separase-associated but not free securin.

Authors:  Susanne Hellmuth; Franziska Böttger; Cuiping Pan; Matthias Mann; Olaf Stemmann
Journal:  EMBO J       Date:  2014-04-29       Impact factor: 11.598

4.  Positive and negative regulation of vertebrate separase by Cdk1-cyclin B1 may explain why securin is dispensable.

Authors:  Susanne Hellmuth; Christopher Pöhlmann; Andreas Brown; Franziska Böttger; Mathias Sprinzl; Olaf Stemmann
Journal:  J Biol Chem       Date:  2015-02-06       Impact factor: 5.157

5.  Orthologues of the anaphase-promoting complex/cyclosome coactivators Cdc20p and Cdh1p are important for mitotic progression and morphogenesis in Candida albicans.

Authors:  Hsini Chou; Amandeep Glory; Catherine Bachewich
Journal:  Eukaryot Cell       Date:  2011-03-11

6.  Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin.

Authors:  D Huertas; M Soler; J Moreto; A Villanueva; A Martinez; A Vidal; M Charlton; D Moffat; S Patel; J McDermott; J Owen; D Brotherton; D Krige; S Cuthill; M Esteller
Journal:  Oncogene       Date:  2011-08-01       Impact factor: 9.867

7.  Conserved CDC20 cell cycle functions are carried out by two of the five isoforms in Arabidopsis thaliana.

Authors:  Zoltán Kevei; Mikhail Baloban; Olivier Da Ines; Hilda Tiricz; Alexandra Kroll; Krzysztof Regulski; Peter Mergaert; Eva Kondorosi
Journal:  PLoS One       Date:  2011-06-08       Impact factor: 3.240

8.  Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I.

Authors:  Yufei Li; Leyun Wang; Linlin Zhang; Zhengquan He; Guihai Feng; Hao Sun; Jiaqiang Wang; Zhikun Li; Chao Liu; Jiabao Han; Junjie Mao; Pengcheng Li; Xuewei Yuan; Liyuan Jiang; Ying Zhang; Qi Zhou; Wei Li
Journal:  J Cell Biol       Date:  2019-02-15       Impact factor: 10.539

9.  A cell cycle timer for asymmetric spindle positioning.

Authors:  Erin K McCarthy Campbell; Adam D Werts; Bob Goldstein
Journal:  PLoS Biol       Date:  2009-04-21       Impact factor: 8.029

10.  Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I.

Authors:  Théodora Niault; Khaled Hached; Rocío Sotillo; Peter K Sorger; Bernard Maro; Robert Benezra; Katja Wassmann
Journal:  PLoS One       Date:  2007-11-28       Impact factor: 3.240
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