Literature DB >> 16338072

Protein tyrosine-phosphatase expression profiling in gastric cancer tissues.

Chew-Wun Wu1, Hwa-Li Kao, Anna F-Y Li, Chin-Wen Chi, Wen-Chang Lin.   

Abstract

Protein phosphorylation is an important regulatory mechanism involved in signal transduction and cancers. In comparison to the extensive tyrosine-kinase oncogenesis research, there are only relatively few studies of protein tyrosine-phosphatase expression in cancers. The expression profile for tyrosine-phosphatases was investigated in gastric cancers using RT-PCR and molecular cloning. The present study showed a general PTP expression profile in gastric cancer tissues, with the identification of 22 distinct tyrosine-phosphatases. Following the examination of five PTPs (PTPRA, PTPRB, PTPRD, PTPRG and PTPRZ) using immunohistochemistry, strong association was observed between PTPRA/PTPRZ expression and gastric cancer progression including lymphovascular invasion and liver/peritoneal dissemination.

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Year:  2005        PMID： 16338072     DOI： 10.1016/j.canlet.2005.10.046

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  25 in total

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