| Literature DB >> 16337931 |
Maria H Nikolova1, Maria N Muhtarova, Hristo B Taskov, Kostadin Kostov, Ljubomir Vezenkov, Antoaneta Mihova, Laurence Boumsell, Armand Bensussan.
Abstract
We investigated the circulating cytotoxic CD160+ CD8(high) subset in correlation to antiviral immunity and response to highly active antiretroviral therapy (HAART) in HIV+ subjects. The study included 45 treatment-naive patients receiving HAART for 18 months, retrospectively defined as good (n=29) and transient (n=16) responders. HIV-specific CD8 T lymphocyte levels were measured by IFNgamma production in response to p17 Gag, in the presence of immobilized anti-CD160 mAb. We report a significantly increased baseline level of CD160+ CD8(high) subset in good therapy responders. CD160+ CD8(high) subset correlates with CD4+ T cell count, immune activation, and viral load. CD160+ CD8(high) lymphocytes contain a high amount of Granzyme B and include virus-specific T lymphocytes in HIV-1+ subjects. Co-stimulation through CD160 molecules enhances IFNgamma production in response to p17 Gag. Therefore, the CD160+ CD8(high) subset may be useful for monitoring of virus-specific cellular immunity and predicting response to antiretroviral therapy in chronic HIV-1 infection.Entities:
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Year: 2005 PMID： 16337931 DOI： 10.1016/j.cellimm.2005.01.012
Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868