Literature DB >> 16337863

Masked Philadelphia chromosome due to atypical BCR/ABL localization on the 9q34 band and duplication of the der(9) in a case of chronic myelogenous leukemia.

Giuseppina Fugazza1, Anna Garuti, Stefania Marchelli, Maurizio Miglino, Roberto Bruzzone, Anna Maria Gatti, Sandra Castello, Mario Sessarego.   

Abstract

The cytogenetic studies and molecular evaluation of a Philadelphia chromosome negative chronic myelogenous leukemia patient with trisomy 21 (100% metaphases) and trisomy 9 (50% metaphases) at diagnosis are described. Fluorescence in situ hybridization revealed an atypical location of the BCR/ABL fusion signal on 9q, which was duplicated in cells with trisomy 9 simulating a double Ph. The patient was successfully treated with Glivec (also known as Gleevec; Novartis, Basel, Switzerland) and achieved complete hematological and cytogenetic response as well as a reduction of BCR/ABL transcripts detected by real-time quantitative PCR.

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Year:  2005        PMID： 16337863     DOI： 10.1016/j.cancergencyto.2005.05.010

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  7 in total

1.  Molecular cytogenetic characterization of Philadelphia-negative rearrangements in chronic myeloid leukemia patients.

Authors:  Ayda Bennour; Hatem Bellâaj; Yosra Ben Youssef; Moez Elloumi; Abderrahim Khelif; Ali Saad; Halima Sennana
Journal:  J Cancer Res Clin Oncol       Date:  2011-07-08       Impact factor: 4.553

2.  Chronic myeloid leukemia with insertion-derived BCR-ABL1 fusion: redefining complex chromosomal abnormalities by correlation of FISH and karyotype predicts prognosis.

Authors:  Zhenya Tang; Gokce A Toruner; Guilin Tang; C Cameron Yin; Wei Wang; Shimin Hu; Beenu Thakral; Sa A Wang; Roberto N Miranda; Joseph D Khoury; L Jeffrey Medeiros
Journal:  Mod Pathol       Date:  2020-05-13       Impact factor: 7.842

3.  Detection of DNA fusion junctions for BCR-ABL translocations by Anchored ChromPET.

Authors:  Yoshiyuki Shibata; Ankit Malhotra; Anindya Dutta
Journal:  Genome Med       Date:  2010-09-22       Impact factor: 11.117

4.  Cryptic BCR-ABL fusion gene as variant rearrangement in chronic myeloid leukemia: molecular cytogenetic characterization and influence on TKIs therapy.

Authors:  Simona Luatti; Carmen Baldazzi; Giulia Marzocchi; Gaia Ameli; Maria Teresa Bochicchio; Simona Soverini; Fausto Castagnetti; Mario Tiribelli; Gabriele Gugliotta; Giovanni Martinelli; Michele Baccarani; Michele Cavo; Gianantonio Rosti; Nicoletta Testoni
Journal:  Oncotarget       Date:  2017-05-02

5.  Chronic Myeloid Leukemia with cryptic Philadelphia translocation and extramedullary B-lymphoid blast phase as an initial presentation.

Authors:  Dina S Soliman; Aliaa M Amer; Deena Mudawi; Zafar Al-Sabbagh; Einas Alkuwari; Ahmad Al-Sabbagh; Feryal Ibrahim; Mohamed A Yassin
Journal:  Acta Biomed       Date:  2018-04-03

6.  FISH mapping of Philadelphia negative BCR/ABL1 positive CML.

Authors:  Anna Virgili; Diana Brazma; Alistair G Reid; Julie Howard-Reeves; Mikel Valgañón; Anastasios Chanalaris; Valeria As De Melo; David Marin; Jane F Apperley; Colin Grace; Ellie P Nacheva
Journal:  Mol Cytogenet       Date:  2008-07-18       Impact factor: 2.009

7.  Masked inv dup(22)(q11.23), tetrasomy 8 and trisomy 19 in a blast crisis-chronic myeloid leukemia after interrupted Imatinib-treatment.

Authors:  Abdulsamad Wafa; Suher Almedani; Thomas Liehr; Walid Al-Achkar
Journal:  Mol Cytogenet       Date:  2015-12-23       Impact factor: 2.009
  7 in total

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