Literature DB >> 16337759

Triallelic patterns in STR loci used for paternity analysis: evidence for a duplication in chromosome 2 containing the TPOX STR locus.

Matti Lukka1, Gunnar Tasa, Pekka Ellonen, Kirsi Moilanen, Vitali Vassiljev, Ismo Ulmanen.   

Abstract

We report triallelic patterns in several short tandem repeat (STR) loci revealed by routine paternity testing using the commercial AMPFlSTR Profiler and AMPFlSTR SGMplus kits. One case where the TPOX-locus (2p25.3) produced three peaks from the blood sample of a child was analysed further. Quantitative polymerase chain reaction (QPCR) and STR typing of the DNAs of the family trio revealed a large (>1.59 Mb) duplication flanking the TPOX-locus in chromosome 2 in both the mother and child. The implications of such genetic anomalies for paternity testing are discussed.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16337759     DOI： 10.1016/j.forsciint.2005.11.006

Source DB:  PubMed          Journal:  Forensic Sci Int        ISSN： 0379-0738            Impact factor:   2.395


  2 in total

1.  Variant alleles, triallelic patterns, and point mutations observed in nuclear short tandem repeat typing of populations in Bosnia and Serbia.

Authors:  René L M Huel; Lara Basić; Kamelija Madacki-Todorović; Lejla Smajlović; Izet Eminović; Irfan Berbić; Ana Milos; Thomas J Parsons
Journal:  Croat Med J       Date:  2007-08       Impact factor: 1.351

2.  Characterization of the extra copy of TPOX locus with tri-allelic pattern.

Authors:  Qinrui Yang; Baonian Liu; Chengchen Shao; Yuxiang Zhou; Yining Yao; Yuyin Pan; Kuan Sun; Hongmei Xu; Chengtao Li; Ting Wei; Yueqin Zhou; Qiqun Tang; Jianhui Xie
Journal:  BMC Genet       Date:  2019-02-14       Impact factor: 2.797
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.