BACKGROUND: Emerging biologic and epidemiologic evidence suggests benefits of insulin-like growth factor-I (IGF-I) in cognitive aging. OBJECTIVE: To examine the relation of circulating IGF-I to cognition. METHODS: We measured plasma IGF-I and IGF-binding protein-3 (IGFBP-3) in 590 women aged 60-68 years. An average 10 years later, we administered telephone-based tests of general cognition (Telephone Interview of Cognitive Status [TICS]), verbal memory, category fluency, and attention. We estimated multivariable-adjusted mean differences in performance across levels of IGF-I/IGFBP-3 molar ratio. RESULTS: On the TICS, each standard deviation (S.D.) increase in molar ratio was significantly associated with better performance: multivariable-adjusted mean difference=0.2 units, 95% confidence interval (0.0,0.4), p=0.05. This effect estimate for each S.D. increase in molar ratio was cognitively equivalent to the mean difference we observed on the TICS between women 1 year apart in age. On a global score combining all tests, there was also a trend of better performance with each S.D. increase in molar ratio (p=0.07). IGF-I levels were not associated with performance in verbal memory. CONCLUSIONS: Higher IGF-I levels may be associated with better general cognition.
BACKGROUND: Emerging biologic and epidemiologic evidence suggests benefits of insulin-like growth factor-I (IGF-I) in cognitive aging. OBJECTIVE: To examine the relation of circulating IGF-I to cognition. METHODS: We measured plasma IGF-I and IGF-binding protein-3 (IGFBP-3) in 590 women aged 60-68 years. An average 10 years later, we administered telephone-based tests of general cognition (Telephone Interview of Cognitive Status [TICS]), verbal memory, category fluency, and attention. We estimated multivariable-adjusted mean differences in performance across levels of IGF-I/IGFBP-3 molar ratio. RESULTS: On the TICS, each standard deviation (S.D.) increase in molar ratio was significantly associated with better performance: multivariable-adjusted mean difference=0.2 units, 95% confidence interval (0.0,0.4), p=0.05. This effect estimate for each S.D. increase in molar ratio was cognitively equivalent to the mean difference we observed on the TICS between women 1 year apart in age. On a global score combining all tests, there was also a trend of better performance with each S.D. increase in molar ratio (p=0.07). IGF-I levels were not associated with performance in verbal memory. CONCLUSIONS: Higher IGF-I levels may be associated with better general cognition.
Authors: Riley M Bove; Anu V Gerweck; Sarah M Mancuso; Miriam A Bredella; Janet C Sherman; Karen K Miller Journal: Obesity (Silver Spring) Date: 2016-02-16 Impact factor: 5.002
Authors: Gang Hu; Ronald Horswell; Yujie Wang; Wei Li; Jay Besse; Ke Xiao; Honglei Chen; Jeffrey N Keller; Steven B Heymsfield; Donna H Ryan; Peter T Katzmarzyk Journal: PLoS One Date: 2012-09-05 Impact factor: 3.240