| Literature DB >> 16337118 |
Fabrizio Micheli1, Paolo Cavanni, Romano Di Fabio, Carla Marchioro, Daniele Donati, Stefania Faedo, Micaela Maffeis, Fabio Maria Sabbatini, Maria Elvira Tranquillini.
Abstract
Exploiting the SAR of the known pyrrole derivatives, a new class of mGluR1 antagonists was developed through a cyclization of the C-2 position on the pyrrole N-1 nitrogen. The resulting pyrrolo[1,2-a]pyrazinones are potent and noncompetitive antagonists.Entities:
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Year: 2005 PMID： 16337118 DOI： 10.1016/j.bmcl.2005.11.049
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823