Literature DB >> 16336344

Mumps orchitis in the non-immune postpubertal male: a resurgent threat to male fertility?

Joe Philip1, David Selvan, Anthony D Desmond.   

Abstract

OBJECTIVE: To report clinical findings associated with an increased incidence of mumps orchitis in Liverpool, UK, as in the last 2 years there has been a four-fold increase in the number of notified viral mumps cases in the UK. PATIENTS AND METHODS: In the 8 months before April 2005, patients presenting to the Accident and Emergency/Urology Departments of the Royal Liverpool University Hospital with a diagnosis of epididymo-orchitis were identified from the emergency urological admission database.
RESULTS: Of 195 males presenting with an acute history of testicular pain and swelling, 25 gave a history of mumps parotitis 4-11 days earlier. Three had bilateral orchitis and two needed scrotal exploration to exclude torsion. Scrotal ultrasonography findings varied from increased vascularity to abnormal testicular echo texture. Treatment included analgesia, scrotal support, re-hydration and broad-spectrum antibiotics. Of the 10 patients followed-up to date, four had testicular abnormalities; one had persistent testicular pain, one a change in testicular consistency, one a noticeably reduced size of one testis, and one significant testicular atrophy.
CONCLUSION: As postpubertal mumps in males is associated with a 40% incidence of orchitis, parents should be made aware that failing to immunize their children threatens the future fertility of their sons. Young men not immunized as children should be counselled and offered urgent vaccination. Clinicians should be aware that epididymo-orchitis may be secondary to mumps infection even with no history or clinical evidence of parotitis.

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Year:  2006        PMID: 16336344     DOI: 10.1111/j.1464-410X.2006.05902.x

Source DB:  PubMed          Journal:  BJU Int        ISSN: 1464-4096            Impact factor:   5.588


  13 in total

Review 1.  [Orchitis and male infertility].

Authors:  H-C Schuppe; A Pilatz; H Hossain; A Meinhardt; M Bergmann; G Haidl; W Weidner
Journal:  Urologe A       Date:  2010-05       Impact factor: 0.639

2.  Long-term efficacy and safety of interferon-alpha-2B in patients with mumps orchitis.

Authors:  Turgut Yapanoglu; Huseyin Kocaturk; Yilmaz Aksoy; Fatih Alper; Isa Ozbey
Journal:  Int Urol Nephrol       Date:  2010-04-30       Impact factor: 2.370

3.  Mumps virus infection disrupts blood-testis barrier through the induction of TNF-α in Sertoli cells.

Authors:  Han Wu; Xing Jiang; Yunxiao Gao; Weihua Liu; Fei Wang; Maolei Gong; Ran Chen; Xiaoqin Yu; Wenjing Zhang; Bo Gao; Chengyi Song; Daishu Han
Journal:  FASEB J       Date:  2019-08-26       Impact factor: 5.191

4.  Role of Infection and Leukocytes in Male Infertility.

Authors:  Sandipan Das; Shubhadeep Roychoudhury; Shatabhisha Roychoudhury; Ashok Agarwal; Ralf Henkel
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 2.622

5.  Immunologic Environment of the Testis.

Authors:  Maolei Gong; Daishu Han
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 6.  Mumps orchitis.

Authors:  M Masarani; H Wazait; M Dinneen
Journal:  J R Soc Med       Date:  2006-11       Impact factor: 18.000

Review 7.  Hypogonadism in the HIV-Infected Man.

Authors:  Nicholas Wong; Miles Levy; Iain Stephenson
Journal:  Curr Treat Options Infect Dis       Date:  2017-02-14

8.  Clinical features of mumps orchitis in vaccinated postpubertal males: a single-center series of 62 patients.

Authors:  Bum Sik Tae; Byeong Kuk Ham; Jae Heon Kim; Jae Young Park; Jae Hyun Bae
Journal:  Korean J Urol       Date:  2012-12-20

9.  Mumps virus-induced innate immune responses in mouse Sertoli and Leydig cells.

Authors:  Han Wu; Lili Shi; Qing Wang; Lijing Cheng; Xiang Zhao; Qiaoyuan Chen; Qian Jiang; Min Feng; Qihan Li; Daishu Han
Journal:  Sci Rep       Date:  2016-01-18       Impact factor: 4.379

10.  Estimating true hospital morbidity of complications associated with mumps outbreak, England, 2004/05.

Authors:  C F Yung; M Ramsay
Journal:  Euro Surveill       Date:  2016-08-18
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