Literature DB >> 1633420

Regulation of p21ras by GTPase activating proteins and guanine nucleotide exchange proteins.

J Downward1.   

Abstract

Ras proteins play a critical role in controlling normal cellular growth and, when activated by mutation, in causing malignant transformation. Regulation of p21ras is achieved by GTPase activating proteins, which control the rate of hydrolysis of GTP to GDP, and also by GDP dissociation stimulators, which catalyze the exchange of guanine nucleotides. Several such proteins have now been identified and their control mechanisms characterized.

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Year:  1992        PMID： 1633420     DOI： 10.1016/s0959-437x(05)80315-6

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  10 in total

1.  T-cell antigen receptor signal transduction.

Authors:  Doreen A Cantrell
Journal:  Immunology       Date:  2002-04       Impact factor: 7.397

2.  Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis.

Authors:  Y Ohba; K Ikuta; A Ogura; J Matsuda; N Mochizuki; K Nagashima; K Kurokawa; B J Mayer; K Maki; J Miyazaki ; M Matsuda
Journal:  EMBO J       Date:  2001-07-02       Impact factor: 11.598

3.  Complementation of defective colony-stimulating factor 1 receptor signaling and mitogenesis by Raf and v-Src.

Authors:  N Aziz; H Cherwinski; M McMahon
Journal:  Mol Cell Biol       Date:  1999-02       Impact factor: 4.272

Review 4.  Signal transduction pathways and their relevance in human astrocytomas.

Authors:  M M Feldkamp; N Lau; A Guha
Journal:  J Neurooncol       Date:  1997-12       Impact factor: 4.130

5.  Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling.

Authors:  P Villalonga; C López-Alcalá; M Bosch; A Chiloeches; N Rocamora; J Gil; R Marais; C J Marshall; O Bachs; N Agell
Journal:  Mol Cell Biol       Date:  2001-11       Impact factor: 4.272

6.  Mechanism of the spatio-temporal regulation of Ras and Rap1.

Authors:  Yusuke Ohba; Kazuo Kurokawa; Michiyuki Matsuda
Journal:  EMBO J       Date:  2003-02-17       Impact factor: 11.598

7.  Amplification, up-regulation and over-expression of C3G (CRK SH3 domain-binding guanine nucleotide-releasing factor) in non-small cell lung cancers.

Authors:  Tomomi Hirata; Hisaki Nagai; Kiyoshi Koizumi; Keiko Okino; Akima Harada; Masamitsu Onda; Takemitsu Nagahata; Iwao Mikami; Kyoji Hirai; Syuji Haraguchi; Enjing Jin; Oichi Kawanami; Kazuo Shimizu; Mitsuru Emi
Journal:  J Hum Genet       Date:  2004-05-08       Impact factor: 3.172

8.  Distinct Ras effector pathways are involved in Fc epsilon R1 regulation of the transcriptional activity of Elk-1 and NFAT in mast cells.

Authors:  H Turner; D A Cantrell
Journal:  J Exp Med       Date:  1997-01-06       Impact factor: 14.307

9.  p21ras mediates control of IL-2 gene promoter function in T cell activation.

Authors:  S I Rayter; M Woodrow; S C Lucas; D A Cantrell; J Downward
Journal:  EMBO J       Date:  1992-12       Impact factor: 11.598

10.  p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells.

Authors:  M Woodrow; N A Clipstone; D Cantrell
Journal:  J Exp Med       Date:  1993-11-01       Impact factor: 14.307
  10 in total

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