BACKGROUND: The aim of the present study was to determine the prognostic significance of the combined overexpression of epidermal growth factor receptor (EGFR) and estrogen receptor a (ER-alpha) in non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: An immunohistochemical assessment of EGFR and ER-alpha expression was carried out in tumor specimens from 122 consecutive NSCLC patients after surgery. RESULTS: Of the 122 tumors examined, 57 (46.7%) overexpressed EGFR, 63 (51.6%) overexpressed ER-alpha, while 33 (27%) overexpressed both EGFR and ER-alpha. Univariate analyses showed that the overexpression of EGFR or ER-alpha correlated with the histological grade (p = 0.01 and p = 0.03, respectively) and a poorer prognosis (p = 0.007), while overexpression of ER-alpha also correlated with smoking (p = 0.02). Multivariate analysis showed the combined overexpression of EGFR and ER-alpha to be an independent indicator of poorer prognosis (p = 0.0006). CONCLUSION: The combined overexpression of EGFR and ER-alpha in NCLSC patients is predictive of poor outcome and, thus, represents a valuable prognostic factor.
BACKGROUND: The aim of the present study was to determine the prognostic significance of the combined overexpression of epidermal growth factor receptor (EGFR) and estrogen receptor a (ER-alpha) in non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: An immunohistochemical assessment of EGFR and ER-alpha expression was carried out in tumor specimens from 122 consecutive NSCLCpatients after surgery. RESULTS: Of the 122 tumors examined, 57 (46.7%) overexpressed EGFR, 63 (51.6%) overexpressed ER-alpha, while 33 (27%) overexpressed both EGFR and ER-alpha. Univariate analyses showed that the overexpression of EGFR or ER-alpha correlated with the histological grade (p = 0.01 and p = 0.03, respectively) and a poorer prognosis (p = 0.007), while overexpression of ER-alpha also correlated with smoking (p = 0.02). Multivariate analysis showed the combined overexpression of EGFR and ER-alpha to be an independent indicator of poorer prognosis (p = 0.0006). CONCLUSION: The combined overexpression of EGFR and ER-alpha in NCLSC patients is predictive of poor outcome and, thus, represents a valuable prognostic factor.
Authors: T A Bogush; A S Shaturova; E A Dudko; E A Bogush; B E Polotsky; S A Tyulandin; M I Davydov Journal: Dokl Biochem Biophys Date: 2014-03-16 Impact factor: 0.788
Authors: Maria G Raso; Carmen Behrens; Matthew H Herynk; Suyu Liu; Ludmila Prudkin; Natalie C Ozburn; Denise M Woods; Ximing Tang; Reza J Mehran; Cesar Moran; J Jack Lee; Ignacio I Wistuba Journal: Clin Cancer Res Date: 2009-08-25 Impact factor: 12.531