OBJECTIVE: To assess the prevalence of asthma symptoms and their association with sensitisation to eight allergens and bronchial hyperresponsiveness (BHR) to methacholine. SETTING: A random sample of 1232 adults, aged 22 to 28 years, studied in a Chilean semi-rural area. DESIGN: A cross-sectional design for the purpose of this analysis. RESULTS: The prevalence of wheeze was 27.4% (95%CI 24.9-29.9) and waking with breathlessness 13.7% (95%CI 11.8-15.6), higher than the results of a multi-centre European study. Only 7.8% (95%CI 6.3-9.3) had a positive BHR (< or =8 mg/ml) and 26.3% (95%CI 23.8-28.8) were atopic. The Youden index of asthma symptoms in non-atopic subjects varied from 0.184 to 0.259 when using BHR as gold standard for asthma, and increased from 0.379 to 0.504 among those with positive atopy. Only 4.5% reported asthma, and the Youden index was slightly higher in comparison to the asthma symptom groups. CONCLUSION: The prevalence of asthma symptoms in young adults was high, but only a small proportion of these were sensitised or had a positive BHR. We believe that aetiological studies of asthma should analyse subjects with asthma symptoms separately from those with positive atopic status or positive BHR.
OBJECTIVE: To assess the prevalence of asthma symptoms and their association with sensitisation to eight allergens and bronchial hyperresponsiveness (BHR) to methacholine. SETTING: A random sample of 1232 adults, aged 22 to 28 years, studied in a Chilean semi-rural area. DESIGN: A cross-sectional design for the purpose of this analysis. RESULTS: The prevalence of wheeze was 27.4% (95%CI 24.9-29.9) and waking with breathlessness 13.7% (95%CI 11.8-15.6), higher than the results of a multi-centre European study. Only 7.8% (95%CI 6.3-9.3) had a positive BHR (< or =8 mg/ml) and 26.3% (95%CI 23.8-28.8) were atopic. The Youden index of asthma symptoms in non-atopic subjects varied from 0.184 to 0.259 when using BHR as gold standard for asthma, and increased from 0.379 to 0.504 among those with positive atopy. Only 4.5% reported asthma, and the Youden index was slightly higher in comparison to the asthma symptom groups. CONCLUSION: The prevalence of asthma symptoms in young adults was high, but only a small proportion of these were sensitised or had a positive BHR. We believe that aetiological studies of asthma should analyse subjects with asthma symptoms separately from those with positive atopic status or positive BHR.
Authors: James F Potts; Roberto J Rona; Manuel J Oyarzun; Hugo Amigo; Patricia Bustos Journal: Am J Public Health Date: 2007-07-31 Impact factor: 9.308
Authors: Ramón Suárez-Medina; Silvia Venero-Fernández; Vilma Alvarez-Valdés; Nieves Sardiñas-Baez; Carmona Cristina; Maria Loinaz-Gonzalez; Zunilda Verdecia-Pérez; Barbara Corona-Tamayo; Maria Betancourt-López; John Britton; Andrew W Fogarty Journal: BMJ Open Date: 2020-04-22 Impact factor: 2.692
Authors: Vanessa Garcia-Larsen; James F Potts; Stefano Del Giacco; Patricia Bustos; Patricia V Diaz; Hugo Amigo; Manuel Oyarzun; Roberto J Rona Journal: BMC Pulm Med Date: 2016-08-08 Impact factor: 3.317