Literature DB >> 16332908

Rapid detection of subtype-selective nuclear hormone receptor binding with bacterial genetic selection.

Georgios Skretas1, David W Wood.   

Abstract

Subtype-selective nuclear hormone receptor modulators could potentially allow the development of valuable tissue-specific therapeutics. A simple biosensor that allows subtype-specific nuclear hormone receptor binding to be reflected by the growth phenotype of Escherichia coli cells has been constructed. This system will potentially enable the facile detection or evolution of subtype-selective hormone analogues.

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Year:  2005        PMID： 16332908      PMCID： PMC1317461          DOI： 10.1128/AEM.71.12.8995-8997.2005

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  18 in total

Review 1.  Nuclear-receptor ligands and ligand-binding domains.

Authors:  R V Weatherman; R J Fletterick; T S Scanlan
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Review 2.  What pharmacologists can learn from recent advances in estrogen signalling.

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3.  Estrogen receptor microarrays: subtype-selective ligand binding.

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5.  A bacterial biosensor of endocrine modulators.

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Review 6.  Engineered cell lines as a tool for monitoring biological activity of hormone analogs.

Authors:  A Joyeux; P Balaguer; P Germain; A M Boussioux; M Pons; J C Nicolas
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Authors:  M J Meyers; J Sun; K E Carlson; G A Marriner; B S Katzenellenbogen; J A Katzenellenbogen
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  3 in total

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2.  Application of screening methods, shape signatures and engineered biosensors in early drug discovery process.

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3.  Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors α-1 and β-1.

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  3 in total

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