Literature DB >> 16332438

Design, synthesis, and evaluation of novel 6-chloro-/fluorochromone derivatives as potential topoisomerase inhibitor anticancer agents.

M P S Ishar1, Gurpinder Singh, Satyajit Singh, K K Sreenivasan, Gurmit Singh.   

Abstract

6-Chloro-2-pyrrolidino-/morpholino-/piperidino-/N-methylpiperazino-3-formyl-chromones (13-16) and 6-fluoro-2,7-di-morpholino-/piperidino-/N-methylpiperazino-3-formylchromones (17-19) have been synthesized as potential topoisomerase inhibitor anticancer agents, and evaluated, in vitro, against Ehrlich ascites carcinoma (EAC) cells, and also in vivo on EAC bearing mice. The compounds displayed promising anticancer activity under these test systems and shall serve as useful 'leads' for further design.

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Year:  2005        PMID： 16332438     DOI： 10.1016/j.bmcl.2005.11.044

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Synthesis, characterization, DNA binding, DNA cleavage and antimicrobial studies of Schiff base ligand and its metal complexes.

Authors:  Padmaja Mendu; C Gyana Kumari; Rajesh Ragi
Journal:  J Fluoresc       Date:  2015-02-07       Impact factor: 2.217

2.  4,4'-Unsymmetrically substituted 3,3'-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors.

Authors:  Patrick T Weiser; Ching-Yi Chang; Donald P McDonnell; Robert N Hanson
Journal:  Bioorg Med Chem       Date:  2013-11-08       Impact factor: 3.641

3.  Synthesis and in vitro cytotoxic activity of chromenopyridones.

Authors:  Balwinder Singh; Vishal Sharma; Gagandeep Singh; Rakesh Kumar; Saroj Arora; Mohan Paul Singh Ishar
Journal:  Int J Med Chem       Date:  2012-01-08

4.  Synthesis of Palladium(II) Complexes via Michael Addition: Antiproliferative Effects through ROS-Mediated Mitochondrial Apoptosis and Docking with SARS-CoV-2.

Authors:  Jebiti Haribabu; Swaminathan Srividya; Dharmasivam Mahendiran; Dasararaju Gayathri; Vemula Venkatramu; Nattamai Bhuvanesh; Ramasamy Karvembu
Journal:  Inorg Chem       Date:  2020-11-24       Impact factor: 5.165

5.  Heteropolyacid coupled with cyanoguanidine decorated magnetic chitosan as an efficient catalyst for the synthesis of pyranochromene derivatives.

Authors:  Golnaz Rahimzadeh; Mahmood Tajbakhsh; Mansoureh Daraie; Ali Ayati
Journal:  Sci Rep       Date:  2022-10-11       Impact factor: 4.996

6.  6-Methyl-4-oxo-4H-chromene-3-carbaldehyde.

Authors:  Sammer Yousuf; Asma Mukhtar; Nida Ambreen; Syed Muhammad Saad; Khalid M Khan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-09-12
  6 in total

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