| Literature DB >> 16332437 |
Jinyou Xu1, Lan Wei, Robert Mathvink, Scott D Edmondson, Anthony Mastracchio, George J Eiermann, Huaibing He, Joseph F Leone, Barbara Leiting, Kathryn A Lyons, Frank Marsilio, Reshma A Patel, Aleksandr Petrov, Joseph K Wu, Nancy A Thornberry, Ann E Weber.
Abstract
anti-Substituted beta-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors exhibiting excellent selectivity over both DPP8 and DPP9. The optimized compound exhibited good pharmacokinetic profiles in three preclinical species.Entities:
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Year: 2005 PMID： 16332437 DOI： 10.1016/j.bmcl.2005.11.052
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823