PURPOSE: To determine the effects of L: -carnitine on sperm parameters in patients with idiopathic sperm abnormalities. METHODS: In an academic reproductive care center, 170 patients including 48 smokers and 122 non-smokers participated in a before-after study. Men were given 1 g of L: -carnitine orally 3 x daily for 3 months. Sperm assessment was done before and after the treatment. Main outcome measures were sperm concentration, motility, and morphology before and after the treatment. RESULTS: L-Carnitine was effective in improvement of percentile of motile sperms, grade A sperms, and normal-shaped sperms. L-Carnitine significantly improved percentile of motile and grade A sperms in non-smokers. Only the change in the median percentile of normal forms was within the significant range in smokers. CONCLUSIONS: The results of this study indicate that smoker patients should not be excluded from the treatment with L-carnitine based on smoking alone.
PURPOSE: To determine the effects of L: -carnitine on sperm parameters in patients with idiopathic sperm abnormalities. METHODS: In an academic reproductive care center, 170 patients including 48 smokers and 122 non-smokers participated in a before-after study. Men were given 1 g of L: -carnitine orally 3 x daily for 3 months. Sperm assessment was done before and after the treatment. Main outcome measures were sperm concentration, motility, and morphology before and after the treatment. RESULTS:L-Carnitine was effective in improvement of percentile of motile sperms, grade A sperms, and normal-shaped sperms. L-Carnitine significantly improved percentile of motile and grade A sperms in non-smokers. Only the change in the median percentile of normal forms was within the significant range in smokers. CONCLUSIONS: The results of this study indicate that smoker patients should not be excluded from the treatment with L-carnitine based on smoking alone.
Authors: W Y Wong; C M Thomas; H M Merkus; G A Zielhuis; W H Doesburg; R P Steegers-Theunissen Journal: Fertil Steril Date: 2000-11 Impact factor: 7.329
Authors: Michael Zitzmann; Claus Rolf; Verena Nordhoff; Guido Schräder; Melanie Rickert-Föhring; Paul Gassner; Hermann M Behre; Robert R Greb; Ludwig Kiesel; Eberhard Nieschlag Journal: Fertil Steril Date: 2003-06 Impact factor: 7.329