| Literature DB >> 16330321 |
Carmen A Argmann1, Pierre Chambon, Johan Auwerx.
Abstract
With the completion of the many genomes, genetics is positioned to meet physiology. In this review, we summarize the coming of "systems metabolism" in mammals through the use of the mouse, as a model system to study metabolism. Building on mouse genetics with increasingly sophisticated clinical and molecular phenotyping strategies has enabled scientists to now tackle complex biomedical questions, such as those related to the pathogenesis of the common metabolic disorders. The ultimate goal of such strategies will be to mimic human metabolism with the click of a mouse.Entities:
Mesh：
Year: 2005 PMID： 16330321 DOI： 10.1016/j.cmet.2005.11.002
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287