Role of dietary l-arginine supplementation on serum parameters and intestinal enzyme activities in rats fed an excess-fat diet.

We investigated whether dietary supplementation with L-arginine, the endogenous precursor of nitric oxide, might affect serum parameter levels body weight, food intake and activities of intestinal mucosa enzymes in animals fed with a standard diet or a diet high in saturated fat for 4 weeks. Body weight and food intake were not affected by diet but relative liver weight was higher in animals receiving a high-fat diet. Total cholesterol, LDL-cholesterol and triglyceride levels were higher in both groups fed high-fat diet and dietary L-arginine did not affect these parameters but produced an increase in serum protein levels and a slight decrease in glycaemia. Regarding the intestinal enzyme activities, rats fed a high-fat diet plus arginine showed the lowest intestinal disaccharidase activities.