Literature DB >> 16330022

CART (cocaine- and amphetamine-regulated transcript) peptide receptors: specific binding in AtT20 cells.

Aleksandra Vicentic1, Anita Lakatos, Michael J Kuhar.   

Abstract

Given previous evidence for CART (cocaine- and amphetamine-regulated transcript) signaling in AtT20 cells, the binding of [125I]-CART61-102 was characterized in these cells. The binding was specific, saturable, dependent on time, pH, temperature and protein concentration, with a Bmax of 101.4+/-8.8 fmol/mg protein and a Kd of 21.9+/-8.0 pM. Only active CART55-102, but not other peptides or drugs, inhibited the [125I]-CART61-102 binding. These data are the first demonstration of specific receptor binding for CART peptides.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16330022     DOI： 10.1016/j.ejphar.2005.11.041

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

1.  Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection.

Authors:  Yun Xu; Wenri Zhang; Judith Klaus; Jennifer Young; Ines Koerner; Laird C Sheldahl; Patricia D Hurn; Francisco Martínez-Murillo; Nabil J Alkayed
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-13       Impact factor: 11.205

2.  CART peptide in the nucleus accumbens regulates psychostimulants: Correlations between psychostimulant and CART peptide effects.

Authors:  Martin O Job; Michael J Kuhar
Journal:  Neuroscience       Date:  2017-02-16       Impact factor: 3.590

Review 3.  CART peptides: regulators of body weight, reward and other functions.

Authors:  G Rogge; D Jones; G W Hubert; Y Lin; M J Kuhar
Journal:  Nat Rev Neurosci       Date:  2008-10       Impact factor: 34.870

Review 4.  Orphan neuropeptides and receptors: Novel therapeutic targets.

Authors:  Lloyd D Fricker; Lakshmi A Devi
Journal:  Pharmacol Ther       Date:  2017-11-22       Impact factor: 12.310

5.  CART peptide stimulation of G protein-mediated signaling in differentiated PC12 cells: identification of PACAP 6-38 as a CART receptor antagonist.

Authors:  Yiming Lin; Randy A Hall; Michael J Kuhar
Journal:  Neuropeptides       Date:  2011-08-19       Impact factor: 3.286

6.  Cocaine- and amphetamine-regulated transcript accelerates termination of follicle-stimulating hormone-induced extracellularly regulated kinase 1/2 and Akt activation by regulating the expression and degradation of specific mitogen-activated protein kinase phosphatases in bovine granulosa cells.

Authors:  Aritro Sen; Lihua Lv; Nora Bello; James J Ireland; George W Smith
Journal:  Mol Endocrinol       Date:  2008-09-25

Review 7.  CART peptides as modulators of dopamine and psychostimulants and interactions with the mesolimbic dopaminergic system.

Authors:  George W Hubert; Douglas C Jones; Mark C Moffett; George Rogge; Michael J Kuhar
Journal:  Biochem Pharmacol       Date:  2007-07-26       Impact factor: 5.858

8.  Injection of CART (cocaine- and amphetamine-regulated transcript) peptide into the nucleus accumbens reduces cocaine self-administration in rats.

Authors:  Jason N Jaworski; Stephen T Hansen; Michael J Kuhar; Gregory P Mark
Journal:  Behav Brain Res       Date:  2008-04-07       Impact factor: 3.332

9.  In vivo cerebrovascular effects of cocaine- and amphetamine-regulated transcript (CART) peptide.

Authors:  Jeffrey J Iliff; Nabil J Alkayed; Kiarash J Golshani; Jason Weinstein; Richard J Traystman; G Alexander West
Journal:  J Cardiovasc Pharmacol       Date:  2008-07       Impact factor: 3.105
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.